Astrid Petermann
University of Jena
7 Papers
74 Citations
Astrid Petermann is an academic researcher from University of Jena. The author has contributed to research in topics: Protein tyrosine phosphatase & Platelet-derived growth factor receptor. The author has an hindex of 5, co-authored 7 publications.
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Papers
Loss of the protein-tyrosine phosphatase DEP-1/PTPRJ drives meningioma cell motility.
Astrid Petermann,Daniela Haase,Andrea Wetzel,Kamal Kumar Balavenkatraman,Tencho Tenev,Karl-Heinz Gührs,Sabrina Friedrich,Makoto Nakamura,Christian Mawrin,Christian Mawrin,Frank-D. Böhmer +10 more
TL;DR: It is proposed that negative regulation of PDGF receptor signaling and positive regulation of adhesion signaling by DEP‐1 cooperate in inhibition of meningioma cell motility, and possibly tumor invasiveness.
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Identification of 3‐hydroxy‐β‐damascone and related carotenoid‐derived aroma compounds as novel potent inducers of Nrf2‐mediated phase 2 response with concomitant anti‐inflammatory activity
Clarissa Gerhäuser,Karin Klimo,Wolfgang Hümmer,Jana Hölzer,Astrid Petermann,Antonio Garreta-Rufas,Frank-D. Böhmer,Peter Schreier +7 more
TL;DR: The identification of 3-hydroxy-beta-damascone and related carotenoid derived aroma compounds as potent inducers of NAD(P)H:quinone reductase (QR) activity revealed previously unrecognized cancer chemopreventive potential of aroma compounds, which may contribute to the cancer protective efficacy of apple products and other dietary sources in animal models.
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GSTT2, a phase II gene induced by apple polyphenols, protects colon epithelial cells against genotoxic damage
Astrid Petermann,Claudia Miene,Gabriele Schulz-Raffelt,Katja Palige,Jana Hölzer,Michael Glei,Frank-D. Böhmer +6 more
TL;DR: The results causally link GSTT2 levels with protection from genotoxic stress, and provide evidence that the antigenotoxic effects of apple polyphenols in vitro are at least in part due to an induction of GSTT1 expression.
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The structure of the 5′-end of the protein-tyrosine phosphatase PTPRJ mRNA reveals a novel mechanism for translation attenuation
Luchezar Karagyozov,Rinesh Godfrey,Sylvia-Annette Böhmer,Astrid Petermann,Sebastian Hölters,Arne Östman,Frank-D. Böhmer +6 more
TL;DR: In the absence of uORF these previously unrecognized characteristics of the 5′-end of the mRNA present a novel mechanism to suppress, and potentially to regulate translation.
23
Deficiency of the protein-tyrosine phosphatase DEP-1/PTPRJ promotes matrix metalloproteinase-9 expression in meningioma cells
Astrid Petermann,Yvonn Stampnik,Yan Cui,Helen Morrison,Doreen Pachow,Nadine Kliese,Christian Mawrin,Frank-D. Böhmer +7 more
TL;DR: Induction of MMP-9 expression promoted by DEP-1 deficiency, or potentially by growth factors and inflammatory cytokines, as a mechanism contributing to meningioma brain invasiveness is suggested.
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