Astrid Cornils
Friedrich Miescher Institute for Biomedical Research
4 Papers
Astrid Cornils is an academic researcher from Friedrich Miescher Institute for Biomedical Research. The author has contributed to research in topics: Gene & Phenotype. The author has an hindex of 4, co-authored 4 publications.
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Papers
Two Insulin-like Peptides Antagonistically Regulate Aversive Olfactory Learning in C. elegans
TL;DR: An "ILP-to-ILP" pathway that links environment-sensing neurons, ASI and URX, to the key neuron, RIA, of a network that underlies olfactory plasticity and modulates its activity is revealed.
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An Insulin-to-Insulin Regulatory Network Orchestrates Phenotypic Specificity in Development and Physiology
Diana Andrea Fernandes de Abreu,Antonio Caballero,Pascal Fardel,Nicholas Stroustrup,Zhunan Chen,KyungHwa Lee,William Keyes,Zachary M. Nash,Isaac F. López-Moyado,Federico Vaggi,Astrid Cornils,Martin Regenass,Anca Neagu,Ivan Ostojic,Chang Liu,Yongmin Cho,Deniz Sifoglu,Yu Shen,Walter Fontana,Hang Lu,Attila Csikász-Nagy,Coleen T. Murphy,Adam Antebi,Eric Blanc,Javier Apfeld,Yun Zhang,Joy Alcedo,Quee-Lim Ch'ng +27 more
TL;DR: This work identifies mechanisms for how the forty Caenorhabditis elegans ILPs coordinate diverse processes, including development, reproduction, longevity and several specific stress responses, and identifies an ILP-based combinatorial code for these phenotypes characterized by substantial functional specificity and diversity rather than global redundancy.
Specific insulin-like peptides encode sensory information to regulate distinct developmental processes
TL;DR: It is found that one ILP, ins-1, ensures dauer arrest under harsh environments and that two other ILPs, daf-28 and ins-6, ensure reproductive growth under good conditions and are shown to have non-redundant functions in regulating these developmental switches.
The thioredoxin TRX-1 modulates the function of the insulin-like neuropeptide DAF-28 during dauer formation in Caenorhabditis elegans
TL;DR: It is proposed that TRX-1 acts as a fluctuating neuronal signaling modulator within ASJ neurons to monitor the adjustment of neuropeptide expression, including insulin-like proteins, during dauer formation in response to adverse environmental conditions.