Ashley P. E. Roberts
University of Glasgow
6 Papers
73 Citations
Ashley P. E. Roberts is an academic researcher from University of Glasgow. The author has contributed to research in topics: Viral tegument & Herpes simplex virus. The author has an hindex of 6, co-authored 6 publications.
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Papers
Differing Roles of Inner Tegument Proteins pUL36 and pUL37 during Entry of Herpes Simplex Virus Type 1
Ashley P. E. Roberts,Fernando Abaitua,Peter O'Hare,David McNab,Frazer J. Rixon,David Pasdeloup +5 more
TL;DR: Visualization of virus DNA replication showed that a UL37-minus mutant was capable of transmitting infection to all the nuclei within a syncytium as efficiently as the wild-type HSV-1 strain 17+ did, whereas infection by UL36-minus mutants failed to spread.
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Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection.
Thamir A. Alandijany,Thamir A. Alandijany,Ashley P. E. Roberts,Kristen L. Conn,Kristen L. Conn,Colin Loney,Steven McFarlane,Anne Orr,Chris Boutell +8 more
TL;DR: Dual roles for PML are identified in the sequential regulation of intrinsic and innate immunity to HSV-1 infection that are dependent on viral genome delivery to the nucleus and the onset of vDNA replication, respectively.
The large tegument protein pUL36 is essential for formation of the capsid vertex-specific component at the capsid-tegument interface of herpes simplex virus 1
TL;DR: It is shown that the largest viral protein, pUL36, which occupies the layer of tegument closest to the capsid, is essential for formation of structurally normal connections to the Capsid.
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Inner tegument protein pUL37 of herpes simplex virus type 1 is involved in directing capsids to the trans-Golgi network for envelopment.
David Pasdeloup,Frauke Beilstein,Ashley P. E. Roberts,Marion McElwee,David McNab,Frazer J. Rixon +5 more
TL;DR: It is concluded that the inner tegument protein pUL37 is required for directing capsids to the TGN, where secondary envelopment of herpes simplex virus type 1 occurs.
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