Ashley I. Bush
Florey Institute of Neuroscience and Mental Health
610 Papers
3.7K Citations
Ashley I. Bush is an academic researcher from Florey Institute of Neuroscience and Mental Health. The author has contributed to research in topics: Medicine & Alzheimer's disease. The author has an hindex of 116, co-authored 560 publications. Previous affiliations of Ashley I. Bush include University of Melbourne & Royal Melbourne Hospital.
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Papers
Amyloid β-mediated Zn2+ influx into dentate granule cells transiently induces a short-term cognitive deficit.
Atsushi Takeda,Masatoshi Nakamura,Hiroaki Fujii,Chihiro Uematsu,Tatsuya Minamino,Paul A. Adlard,Ashley I. Bush,Haruna Tamano +7 more
TL;DR: It is indicated that Aβ-mediated Zn2+ influx into dentate granule cells, which may occur without AMPA receptor activation, transiently induces a short-term cognitive deficit.
Involvement of hippocampal excitability in amyloid β-induced behavioral and psychological symptoms of dementia.
TL;DR: It is likely that behavioral abnormality of Aβ1-42-injected adult mice is associated with excitability of hippocampal glutamatergic neurons, which isassociated with the elevated corticosterone level.
Amyloid-β Metal Interaction and Metal Chelation
TL;DR: The interaction of Aβ with metals, metal dyshomeostasis in the CNS of patients with AD, and the potential therapeutic effects of metal chelators are discussed.
Iron accumulation in skeletal muscles of old mice is associated with impaired regeneration after ischaemia–reperfusion damage
Francesca M. Alves,Francesca M. Alves,Kai Kysenius,Marissa K. Caldow,Justin P. Hardee,Peter J. Crouch,Scott Ayton,Ashley I. Bush,Gordon S. Lynch,René Koopman +9 more
TL;DR: In this paper, the role of iron in muscle atrophy and muscle regeneration after ischaemia-reperfusion (IR) injury was examined in 3-month-old and 24-month old mice.
Apolipoprotein E ablation decreases synaptic vesicular zinc in the brain.
Joo Yong Lee,Joo Yong Lee,Eunsil Cho,Tae-Youn Kim,Tae-Youn Kim,Dong-Kyu Kim,Dong-Kyu Kim,Richard D. Palmiter,Irene Volitakis,Irene Volitakis,Jong S. Kim,Ashley I. Bush,Ashley I. Bush,Jae-Young Koh,Jae-Young Koh +14 more
TL;DR: The results suggest that apoE may affect the cerebral free zinc pool that contributes to AD pathology.