Ashley I. Bush
Florey Institute of Neuroscience and Mental Health
610 Papers
3.7K Citations
Ashley I. Bush is an academic researcher from Florey Institute of Neuroscience and Mental Health. The author has contributed to research in topics: Medicine & Alzheimer's disease. The author has an hindex of 116, co-authored 560 publications. Previous affiliations of Ashley I. Bush include University of Melbourne & Royal Melbourne Hospital.
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Papers
Targeting the progression of Parkinson's disease.
Jessica L George,Su San Mok,David Moses,Simon Wilkins,Ashley I. Bush,Robert A. Cherny,David Finkelstein +6 more
TL;DR: The main thrust of this review is to explore the interactions between dopamine, alpha synuclein and redox-active metals to identify therapeutic targets to mitigate the progression of this debilitating disease.
The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease
David Finkelstein,Jessica L. Billings,Paul A. Adlard,Scott Ayton,Amelia Sedjahtera,Colin L. Masters,Simon Wilkins,David M. Shackleford,Susan A. Charman,Wojciech Bal,Izabela Zawisza,Ewa Kurowska,Andrew L. Gundlach,Sherie Ma,Ashley I. Bush,Dominic J. Hare,Dominic J. Hare,Philip Doble,Simon Crawford,Elisabeth Gautier,Jack Gordon Parsons,Penny Huggins,Kevin J. Barnham,Kevin J. Barnham,Robert A. Cherny +24 more
TL;DR: It is concluded that compounds designed to target a pool of pathological iron that is not held in high-affinity complexes in the tissue can maintain the survival of SNpc neurons and could be disease-modifying in PD.
Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer’s Disease
Bárbara Rita Cardoso,Blaine R. Roberts,Charles B Malpas,Lucy Vivash,Lucy Vivash,Sila Genc,Michael M. Saling,Patricia Desmond,Christopher Steward,Rodney J. Hicks,Rodney J. Hicks,Jason Callahan,Amy Brodtmann,Amy Brodtmann,Steven J. Collins,Steven J. Collins,Stephen Macfarlane,Niall M. Corcoran,Christopher M. Hovens,Dennis Velakoulis,Terence J. O'Brien,Terence J. O'Brien,Dominic J. Hare,Ashley I. Bush +23 more
TL;DR: High-dose sodium selenate supplementation is well tolerated and can modulate CNS selenium concentration, although individual variation in selenum metabolism must be considered to optimize potential benefits in AD.
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Intracellular Accumulation of Detergent‐Soluble Amyloidogenic Aβ Fragment of Alzheimer's Disease Precursor Protein in the Hippocampus of Aged Transgenic Mice
Qiao-Xin Li,Christa J. Maynard,Roberto Cappai,Catriona McLean,Robert A. Cherny,Toni Lynch,Janetta G. Culvenor,Jim Trevaskis,J.E. Tanner,Karen Bailey,Christian Czech,Ashley I. Bush,Konrad Beyreuther,Colin L. Masters +13 more
TL;DR: This mouse model provides a system to study the intracellular processing and accumulation of Aβ or Aβ‐containing fragments and to screen for compounds directed at the γ‐secretase activity.
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Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons
Adam P Gunn,Bruce X. Wong,Timothy Johanssen,James C. Griffith,Colin L. Masters,Ashley I. Bush,Kevin J. Barnham,James A. Duce,Robert A. Cherny +8 more
TL;DR: Aβ3pE-42 has an enhanced capacity to cause lipid peroxidation in primary cortical mouse neurons compared with the full-length isoform (Aβ(1–42), andPyroglutamate formation was additionally found to increase the relative efficiency of Aβ-dityrosine oligomer formation mediated by copper-redox cycling.
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