Ashley I. Bush
Florey Institute of Neuroscience and Mental Health
610 Papers
3.7K Citations
Ashley I. Bush is an academic researcher from Florey Institute of Neuroscience and Mental Health. The author has contributed to research in topics: Medicine & Alzheimer's disease. The author has an hindex of 116, co-authored 560 publications. Previous affiliations of Ashley I. Bush include University of Melbourne & Royal Melbourne Hospital.
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Papers
Tau protein: Relevance to Parkinson's disease
Peng Lei,Scott Ayton,Scott Ayton,David Finkelstein,David Finkelstein,Paul A. Adlard,Paul A. Adlard,Colin L. Masters,Ashley I. Bush,Ashley I. Bush +9 more
TL;DR: Key genetic, pathological and biochemical evidence supporting a role for tau in the pathogenesis of Parkinson's disease is summarized.
BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells
Diane Moujalled,Adam Southon,Eiman Saleh,Kerstin Brinkmann,Francine Ke,Melinda Iliopoulos,Ryan S Cross,Misty R. Jenkins,Duong Thuy Nhu,Zilu Wang,Melissa X Shi,Ruth M. Kluck,Guillaume Lessene,Stephanie Grabow,Ashley I. Bush,Andreas Strasser +15 more
TL;DR: The combined loss of BAX and BAK, the essential executioners of intrinsic apoptosis, rendered U251 and SNB-19 cells refractory to any of the drug combinations tested, demonstrating that apoptosis is responsible for their killing.
Predicting Alzheimer disease from a blood-based biomarker profile: A 54-month follow-up
Samantha C. Burnham,Christopher C. Rowe,David Baker,Ashley I. Bush,James D. Doecke,Noel G. Faux,Simon M. Laws,Ralph N. Martins,Ralph N. Martins,Paul Maruff,S. Lance Macaulay,S. Lance Macaulay,Stephanie R. Rainey-Smith,Stephanie R. Rainey-Smith,Greg Savage,David Ames,Colin L. Masters,William Wilson,Victor L. Villemagne +18 more
TL;DR: Findings suggest that a simple blood-based signature not only provides estimates of NAB but also predicts cognitive decline and disease progression, identifying individuals at risk of progressing toward AD at the prodromal and preclinical stages.
A role for glutathione in the pathophysiology of bipolar disorder and schizophrenia? Animal models and relevance to clinical practice.
Oliviad M. Dean,M. van den Buuse,M. van den Buuse,Ashley I. Bush,Ashley I. Bush,David L. Copolov,Felicity Ng,Seetal Dodd,Michael Berk,Michael Berk +9 more
TL;DR: Animal models have been established to investigate the involvement of glutathione depletion in aspects of schizophrenia and bipolar disorder to further characterise the role of oxidative stress in psychopathology.
Bioactive poly(2-oxazoline)-based nanomaterials bearing arylalkylamine and benzamide motifs possess intrinsic radical trapping and anti-ferroptosis properties.
TL;DR: In this article , the structural and functional layers of poly(2-oxazoline)-Fer-1 conjugates were analyzed and drug-free POx containing arylalkylamine and benzamide motifs showed anti-ferroptosis properties.