Ashley Drew
3 Papers
Ashley Drew is an academic researcher. The author has contributed to research in topics: Chemistry & Biology. The author has co-authored 3 publications.
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Papers
Nucleotide dependent conformational changes of MutL.
and R P Morgan,Ashley Drew,A. Atisa,Malikiya A. Hinds,Sharonda J. LeBlanc +4 more
TL;DR: In this article , site-directed mutagenesis was used to fluorescently label sites in the different domains of Thermus Aquaticus MutL, including the N-terminal, linker arms, and Cterminal domains, to reveal the specific interactions and conformational changes that are necessary to initiate mismatch repair.
Time-resolved mechanisms of essential biological pathways.
Sharonda J. LeBlanc,A. Morgan,Ashley Drew,Kenya Gordon,Meredith N. Frazier,A. Atisa,Malikiya A. Hinds,Robin E. Stanley +7 more
TL;DR: In this paper , the authors used single molecule time-resolved fluorescence spectroscopy as a tool to explore in real time the protein-nucleic acid interactions and dynamic structural rearrangements that drive specific pathways.
Investigating the impact of ATPase mutation on MutL function.
Ashley Drew,A. Morgan,Sharonda J. LeBlanc +2 more
TL;DR: In this paper , the authors used Thermus Aquaticus MutL as a model system for human MutLalpha and mutated the ATPase domain by changing the glutamic acid in residue 28 to an alanine (E28A, aligned to E34A in human MLH1, a common mutation in Lynch syndrome patients).