Ashley Auerbach
University of Minnesota
9 Papers
1 Citations
Ashley Auerbach is an academic researcher from University of Minnesota. The author has contributed to research in topics: Biology & Coronavirus. The author has an hindex of 4, co-authored 4 publications.
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Papers
Structural basis of receptor recognition by SARS-CoV-2.
Jian Shang,Gang Ye,Ke Shi,Yushun Wan,Chuming Luo,Hideki Aihara,Qibin Geng,Ashley Auerbach,Fang Li +8 more
TL;DR: This study determines the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 (engineered to facilitate crystallization) in complex with ACE2 and sheds light on the structural features that increase its binding affinity to ACE2.
3.8K
Cell entry mechanisms of SARS-CoV-2.
TL;DR: Key cell entry mechanisms of SARS-CoV-2 that potentially contribute to the immune evasion, cell infectivity, and wide spread of the virus are identified using biochemical and pseudovirus entry assays and the potency and evasiveness are highlighted.
3.1K
APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection
Lavanya Manjunath,Sunwoo Oh,Pedro Ortega,Alexis Bouin,Elodie Bournique,Ambrocio Sanchez,Pia M. Martensen,Ashley Auerbach,Jordan T. Becker,Marcus M. Seldin,Reuben S. Harris,Bert L. Semler,Rémi Buisson +12 more
TL;DR: In this paper , APOBEC3B forms a complex with PABPC1 to stimulate PKR and counterbalances the PKR-suppressing activity of ADAR1 in response to infection by many types of viruses.
Ancestral APOBEC3B Nuclear Localization Is Maintained in Humans and Apes and Altered in Most Other Old World Primate Species
Ashley Auerbach,Jordan T. Becker,Sofia N. Moraes,Seyed Arad Moghadasi,Jolene M. Duda,Daniel J. Salamango,Reuben S. Harris +6 more
TL;DR: In this article , the authors combine evolutionary, molecular, and cell biology approaches to address whether nuclear localization is a conserved feature of APOBEC3B in primates, and they show that the ancestral nuclear localization was maintained in present-day human and ape enzymes, but not conserved in other nonhuman primates.
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Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism
Elisa Fanunza,Adam Z. Cheng,Ashley Auerbach,Bojana Stefanovska,Sofia N. Moraes,James R. Lokensgard,Matteo Biolatti,Valentina Dell'Oste,Craig J. Bierle,Wade A. Bresnahan,Reuben S. Harris +10 more
TL;DR: In this article , it was shown that HCMV infection causes the antiviral factor, APOBEC3B, to relocalize from the nuclear compartment to the cytoplasm.