Ashish Thakur
University of Utah
17 Papers
9 Citations
Ashish Thakur is an academic researcher from University of Utah. The author has contributed to research in topics: Cycloaddition & Catalysis. The author has an hindex of 7, co-authored 15 publications. Previous affiliations of Ashish Thakur include National Institutes of Health.
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Papers
Design, Synthesis, and Biological Evaluation of Quinazolin-4-one-Based Hydroxamic Acids as Dual PI3K/HDAC Inhibitors.
Ashish Thakur,Gregory J. Tawa,Mark J. Henderson,Carina Danchik,Suiyang Liu,Pranav Shah,Amy Wang,Garrett Dunn,Kabir,Elias C. Padilha,Xin Xu,Anton Simeonov,Surender Kharbanda,Richard Stone,Gurmit Grewal +14 more
TL;DR: The lead compound 48c, induced necrosis in several mutant and FLT3-resistant AML cell lines and primary blasts from AML patients, while showing no cytotoxicity against normal PBMCs, NIH3T3 and HEK293 cells.
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Nickel‐Catalyzed Cycloaddition of 1,3‐Dienes with 3‐Azetidinones and 3‐Oxetanones
TL;DR: The use of small cyclic systems wherein the release of inherent strain provides the necessary driving force for C-C bond cleavage has been a central theme of C–C bond activation strategies.
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Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides
TL;DR: A protocol for the Suzuki-Miyaura coupling of heteroaryl boronic acids and vinyl chlorides that minimizes protodeboronation is described and a dramatic temperature dependence in product selectivity was observed.
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Ni(NHC)]-catalyzed cycloaddition of diynes and tropone: apparent enone cycloaddition involving an 8π insertion.
TL;DR: A Ni/N-heterocyclic carbene catalyst couples diynes to the C(α)–C(β) double bond of tropone, a type of reaction that is unprecedented for metal-catalyzed cycloadditions with aromatic tropone and has broad substrate scope and tolerates a wide range of functional groups.
An in Situ Approach to Nickel-Catalyzed Cycloaddition of Alkynes and 3-Azetidinones
TL;DR: An efficient and convenient procedure that generates the active Ni(0) catalyst in situ from cheap, air stable Ni(II) precursors is developed for the [4 + 2]-cycloaddition of alkynes and 3-azetidinones.
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