Ashim Paul
Tel Aviv University
37 Papers
191 Citations
Ashim Paul is an academic researcher from Tel Aviv University. The author has contributed to research in topics: Peptide & Amyloid. The author has an hindex of 11, co-authored 37 publications. Previous affiliations of Ashim Paul include Indian Institute of Technology Guwahati.
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Papers
Near UV-Visible electronic absorption originating from charged amino acids in a monomeric protein
Saumya Prasad,Imon Mandal,Shubham Singh,Ashim Paul,Bhubaneswar Mandal,Ravindra Venkatramani,Rajaram Swaminathan +6 more
TL;DR: This work reports 250–800 nm UV-Vis monomeric protein absorption originating from protein backbone– sidechain and sidechain–sidechain charge transfer transitions involving Lys/Glu residues.
Inhibition of Alzheimer's amyloid-β peptide aggregation and its disruption by a conformationally restricted α/β hybrid peptide
TL;DR: A novel conformationally restricted α/β-hybrid peptide that inhibits amyloid formation of Aβ(1-40) and disrupts preformed fibrillar aggregates in vitro is generated.
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Mechanistic insights into remodeled Tau-derived PHF6 peptide fibrils by Naphthoquinone-Tryptophan hybrids.
TL;DR: It is shown that Naphthoquinone-Tryptophan hybrids significantly disrupted the pre-formed fibrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein in vitro, in a dose-dependent manner as evident from ThS assay, CD spectroscopy, and TEM.
Novel Mannitol-Based Small Molecules for Inhibiting Aggregation of α-Synuclein Amyloids in Parkinson's Disease.
TL;DR: The conjugates of Mannitol and naphthoquinone-tryptophan were found to be have low cytotoxicity and reduced toxicity of α-Syn toward SH-SY5Y neuroblastoma cells and can be attractive scaffold for the development of therapeutic agents for PD.
Disaggregation of Amylin Aggregate by Novel Conformationally Restricted Aminobenzoic Acid containing α/β and α/γ Hybrid Peptidomimetics.
Ashim Paul,Sourav Kalita,Sujan Kalita,Piruthivi Sukumar,Piruthivi Sukumar,Bhubaneswar Mandal +5 more
TL;DR: Efficient inhibition of amyloid formation of Amylin and its disruption by a novel class of conformationally restricted β-sheet breaker hybrid peptidomimetics (BSBHps) is demonstrated, which may be useful for newer drug design against T2DM as well as otherAmyloidoses and understanding amyloidalogenesis.