12 Papers
10 Citations
Arvind Parmar is an academic researcher from Australian Nuclear Science and Technology Organisation. The author has contributed to research in topics: Translocator protein & Computer science. The author has an hindex of 7, co-authored 12 publications. Previous affiliations of Arvind Parmar include University of Sydney.
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Papers
Positron emission tomography and functional characterization of a complete PBR/TSPO knockout
Richard B. Banati,Ryan J. Middleton,Ronald Chan,Claire R. Hatty,Winnie Wai-Ying Kam,Candice Quin,Manuel B. Graeber,Arvind Parmar,David Zahra,Paul D. Callaghan,Sandra Fok,Nicholas R. Howell,Marie Gregoire,Alexander M Szabo,Tien Pham,Emma Davis,Guo Jun Liu,Guo Jun Liu +17 more
TL;DR: It is shown that global C57BL/6-Tspotm1GuWu(GuwiyangWurra)-knockout mice are viable with normal growth, lifespan, cholesterol transport, blood pregnenolone concentration, protoporphyrin IX metabolism, fertility and behaviour, and while the activation of microglia after neuronal injury appears to be unimpaired, microglial output is significantly less ATP, suggesting reduced metabolic activity.
Selective, high-contrast detection of syngeneic glioblastoma in vivo.
Richard B. Banati,Paul Wilcox,Ran Xu,Grace Yin,Emily Si,Eric Taeyoung Son,Mauricio Shimizu,R. M. Damian Holsinger,Arvind Parmar,David Zahra,Andrew Arthur,Ryan J. Middleton,Guo Jun Liu,Arnaud Charil,Manuel B. Graeber +14 more
TL;DR: An animal model that allows high-contrast imaging of wild-type glioma cells by positron emission tomography using [18 F]PBR111 using the mitochondrial 18 kDa Translocator Protein (TSPO) combined with the exclusive expression of TSPO makes it possible, for the first time, to unequivocally and with uniquely high biological contrast identify peri-tumoral gliomas cell invasion at preclinical stages in vivo.
Open-field PET: Simultaneous brain functional imaging and behavioural response measurements in freely moving small animals.
Andre Kyme,Georgios I. Angelis,John Eisenhuth,Roger Fulton,Roger Fulton,Victor W Zhou,Genevra Hart,Kata Popovic,Mahmood Akhtar,William J. Ryder,Kelly J. Clemens,Bernard W. Balleine,Arvind Parmar,Arvind Parmar,Giancarlo Pascali,Giancarlo Pascali,Gary Perkins,Steven R. Meikle +17 more
TL;DR: A technique that combines motion‐compensated PET with a robotically‐controlled animal enclosure to enable simultaneous brain imaging and behavioural recordings in unrestrained small animals is reported, giving rise to important applications in behavioural neuroscience.
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Translocator protein localises to CD11b+ macrophages in atherosclerosis.
Chantal Kopecky,Elvis Pandzic,Arvind Parmar,Jeremy Szajer,Victoria Lee,Alexander Dupuy,Andrew Arthur,Sandra Fok,Renee Whan,William J. Ryder,Kerry-Anne Rye,Blake J. Cochran +11 more
TL;DR: The TSPO ligand, 18F-PBR111, is a potential clinical diagnostic tool for the detection and quantification of atherosclerotic lesion progression in humans.
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In vivo [64Cu]CuCl2 PET imaging reveals activity of Dextran-Catechin on tumor copper homeostasis.
Arvind Parmar,Giancarlo Pascali,Giancarlo Pascali,Florida Voli,Luigi Lerra,Eugene Yee,Aria Ahmed-Cox,Kathleen Kimpton,Giuseppe Cirillo,Andrew Arthur,David Zahra,Gita Rahardjo,Guo Jun Liu,Guo Jun Liu,Nigel A. Lengkeek,Federica Saletta,Arnaud Charil,Maria Kavallaris,Orazio Vittorio +18 more
TL;DR: A novel PET imaging method is developed by developing a [64Cu]CuCl2 PET imaging protocol to monitor the activity of the copper-targeting compound Dextran-Catechin in vivo and its effect on tumor copper homeostasis to reveal a potential therapeutic strategy for targeting copper-dependent cancers.
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