Arthur Y. Shaw
University of Arizona
18 Papers
144 Citations
Arthur Y. Shaw is an academic researcher from University of Arizona. The author has contributed to research in topics: Chemistry & Azide. The author has an hindex of 11, co-authored 18 publications. Previous affiliations of Arthur Y. Shaw include Ohio State University.
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Papers
Dyrk1 inhibition improves Alzheimer's disease-like pathology
Caterina Branca,Darren M. Shaw,Ramona Belfiore,Ramona Belfiore,Vijay Gokhale,Arthur Y. Shaw,Christopher Foley,Breland Smith,Christopher Hulme,Travis Dunckley,Bessie Meechoovet,Antonella Caccamo,Salvatore Oddo +12 more
TL;DR: It is found that chronic Dyrk1 inhibition reversed cognitive deficits in 3xTg‐AD mice and was associated with a reduction in amyloid‐β (Aβ) and tau pathology.
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Facile and rapid route for the synthesis of novel norstatine analogs via PADAM-cyclization methodology
TL;DR: Novel methodology for the rapid synthesis of unique conformationally constrained norstatine analogs of potential biological relevance and the applicability of this solution phase methodology to the preparation of a small collection of compounds is discussed.
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Identification of novel DNA methylation inhibitors via a two-component reporter gene system.
Yi-Shiuan Lin,Arthur Y. Shaw,Shi-Gang Wang,Chia-Chen Hsu,I-Wen Teng,Min-Jen Tseng,Tim H M Huang,Ching-Shih Chen,Yu-Wei Leu,Shu-Huei Hsiao +9 more
TL;DR: The data provide a proof-of-concept that procainamide could be pharmacologically exploited to develop novel DNA methylation inhibitors, of which the translational potential in cancer therapy/prevention is currently under investigation.
Aza-Riley Oxidation of Ugi-Azide and Ugi-3CR Products toward Vicinal Tricarbonyl Amides: Two-Step MCR-Oxidation Methodology Accessing Functionalized α,β-Diketoamides and α,β-Diketotetrazoles
TL;DR: This significant extension of the previously described multicomponent reaction-oxidative deamination methodology is proposed to proceed through a mechanistically distinct SeO2-mediated C-N oxidation derived from an active enol of α-amino-β-ketone systems, effectively an aza-Riley oxidation.
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