Arthur E. Wild
University of Southampton
26 Papers
288 Citations
Arthur E. Wild is an academic researcher from University of Southampton. The author has contributed to research in topics: Blastocyst & Receptor. The author has an hindex of 12, co-authored 26 publications.
Chat about Author
Papers
Maternal undernutrition during the preimplantation period of rat development causes blastocyst abnormalities and programming of postnatal hypertension.
TL;DR: The data indicate that long-term programming of postnatal growth and physiology can be induced irreversibly during the preimplantation period of development by maternal protein undernutrition, and proposes that the mildly hyperglycaemic and amino acid-depleted maternal environment generated by undernutrition may act as an early mechanism of programming and initiate conditions of 'metabolic stress', restricting early embryonic proliferation and the generation of appropriately sized stem-cell lineages.
881
Adaptive Responses by Mouse Early Embryos to Maternal Diet Protect Fetal Growth but Predispose to Adult Onset Disease
Adam J. Watkins,Elizabeth Ursell,Rose Panton,Thomas Papenbrock,Lisa J. Hollis,Colm Cunningham,Adrian Wilkins,V. Hugh Perry,Bhavwanti Sheth,Wing Yee Kwong,Judith J. Eckert,Judith J. Eckert,Arthur E. Wild,Mark A. Hanson,Clive Osmond,Tom P. Fleming +15 more
TL;DR: It is demonstrated that in a nutrient-restricted environment, the preimplantation embryo activates physiological mechanisms of developmental plasticity to stablize conceptus growth and enhance postnatal fitness, however, activation of such responses may also lead to adult excess growth and cardiovascular and behavioral diseases.
244
Tight junction assembly during mouse blastocyst formation is regulated by late expression of ZO-1 alpha+ isoform.
Bhavwanti Sheth,Ira Fesenko,Jane E. Collins,Breda Moran,Arthur E. Wild,James M. Anderson,Tom P. Fleming +6 more
TL;DR: Results provide direct evidence from a native epithelium that ZO-1 isoforms perform distinct roles in tight junction assembly and may act as a final rate-limiting step in the synthesis of the tight junction, thereby regulating the time of junction sealing and blastocoele formation in the early embryo.
161
Imprinted gene expression in the rat embryo–fetal axis is altered in response to periconceptional maternal low protein diet
Wing Yee Kwong,Daniel J. Miller,Elizabeth Ursell,Arthur E. Wild,Adrian Wilkins,Clive Osmond,Fred W Anthony,Tom P. Fleming +7 more
TL;DR: The findings demonstrate that one contributor to the alteration in postnatal growth induced by periconceptional maternal LPD may derive from a gender-specific programming of imprinted gene expression originating within the preimplantation embryo itself.
Stimulation of development in vitro by platelet-activating factor receptor ligands released by mouse preimplantation embryos.
TL;DR: It is concluded that an embryo-derived factor related to PAF is secreted by blastomeres during in vitro culture and acts in a receptor-mediated manner to stimulate the rate of development.