Arjan W. Griffioen
VU University Amsterdam
318 Papers
2.8K Citations
Arjan W. Griffioen is an academic researcher from VU University Amsterdam. The author has contributed to research in topics: Angiogenesis & Endothelial stem cell. The author has an hindex of 75, co-authored 284 publications. Previous affiliations of Arjan W. Griffioen include Utrecht University & VU University Medical Center.
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Papers
•Journal Article
Angiogenesis: Potentials for Pharmacologic Intervention in the Treatment of Cancer, Cardiovascular Diseases, and Chronic Inflammation
TL;DR: The potentials, limitations, and challenges within this field of research are discussed, in light of the development of new therapeutic strategies for diseases in which angiogenesis plays an important role.
Anti-angiogenesis for cancer revisited: Is there a role for combinations with immunotherapy?
TL;DR: Judicious dosing of anti-angiogenic treatment can transiently normalize the tumor vasculature by decreasing vascular permeability and improving tumor perfusion and blood flow, and synergize with immunotherapy in this time window.
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Tumour vascularization: sprouting angiogenesis and beyond
Femke Hillen,Arjan W. Griffioen +1 more
TL;DR: It is concluded that future anti-vascular therapies might be most beneficial when based on multimodal anti-angiogenic, anti-vasculogenic mimicry and anti-lymphangiogenesis strategies.
Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging.
Willem J. M. Mulder,Gustav J. Strijkers,Geralda A. F. van Tilborg,Arjan W. Griffioen,Klaas Nicolay +4 more
TL;DR: An overview of different lipidic nanoparticles for use in MRI is given, with the main emphasis on Gd–based contrast agents.
Convergence and Amplification of Toll-Like Receptor (TLR) and Receptor for Advanced Glycation End Products (RAGE) Signaling Pathways via High Mobility Group B1 (HMGB1)
TL;DR: High mobility group B1 can mediate amplification of inflammation and angiogenesis through increased secretion of HMGB1 and increased expression of the receptors it can interact with, as well as its contribution to pathologies involving endothelial cells.
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