Arijit Roy
Tata Consultancy Services
26 Papers
51 Citations
Arijit Roy is an academic researcher from Tata Consultancy Services. The author has contributed to research in topics: Active site & Carbonic anhydrase II. The author has an hindex of 11, co-authored 25 publications. Previous affiliations of Arijit Roy include Joseph Fourier University & Indian Institutes of Technology.
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Papers
The Nature of Transient Dark States in a Photoactivatable Fluorescent Protein
TL;DR: These findings suggest two previously unidentified dark states that display similar distorted chromophores with a transiently ruptured π-electron system and suggest that C(α) protonated dark states may accelerate photobleaching by favoring decarboxylation of the fully conserved Glu212.
Network-Based Analysis of Fatal Comorbidities of COVID-19 and Potential Therapeutics
TL;DR: The protein-protein interaction sub-network captures the effects of viral invasion on fatal comorbidities through critical pathways, and drugs that have effects on these proteinsathways based on gene expression studies are identified.
Human hydroxymethylbilane synthase: Molecular dynamics of the pyrrole chain elongation identifies step-specific residues that cause AIP
Navneet Bung,Arijit Roy,Brenden Chen,Dibyajyoti Das,Meenakshi Pradhan,Makiko Yasuda,Maria I. New,Robert J. Desnick,Gopalakrishnan Bulusu +8 more
TL;DR: In this paper, the authors investigated the role of active-site residues in the stepwise synthesis of tetrapyrrole 1-hydroxymethylbilane (HMB) by using molecular dynamics simulations, mutagenesis, and in vitro expression analyses.
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Transition path sampling study of the conformational fluctuation of His-64 in human carbonic anhydrase II.
Arijit Roy,Srabani Taraphder +1 more
TL;DR: A transition path sampling study of the conformational fluctuation of His-64 that is known to be important in the enzymatic catalysis of human carbonic anhydrase II finds that both Asn-62 and Tyr-7 may contribute toward retaining the His- 64 residue in its outward conformation.
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A Theoretical Study on the Detection of Proton Transfer Pathways in Some Mutants of Human Carbonic Anhydrase II
Arijit Roy,Srabani Taraphder +1 more
TL;DR: The detection of possible proton transfer pathways into the active site of a number of mutants of the enzyme human carbonic anhydrase II (HCA II) is reported and a recently developed method of path search in the protein conformational space is identified to identify hydrogen-bonded networks that can dynamically connect the protein surface to theactive site through fluctuations in protein structure and hydration.
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