Arif B. Ekici
University of Erlangen-Nuremberg
356 Papers
1.5K Citations
Arif B. Ekici is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Medicine & Breast cancer. The author has an hindex of 67, co-authored 316 publications. Previous affiliations of Arif B. Ekici include University of Regensburg & University of California, Los Angeles.
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Papers
Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors
Anja Rudolph,Roger L. Milne,Roger L. Milne,Thérèse Truong,Julia A. Knight,Julia A. Knight,Petra Seibold,Dieter Flesch-Janys,Sabine Behrens,Ursula Eilber,Manjeet K. Bolla,Qin Wang,Joe Dennis,Alison M. Dunning,Mitul Shah,Hannah Munday,Hatef Darabi,Mikael Eriksson,Judith S. Brand,Janet E. Olson,Celine M. Vachon,Emily Hallberg,J. Esteban Castelao,Angel Carracedo,Angel Carracedo,María Dolores Torres,Jingmei Li,Keith Humphreys,Emilie Cordina-Duverger,Florence Menegaux,Henrik Flyger,Børge G. Nordestgaard,Sune F. Nielsen,Betül T. Yesilyurt,Giuseppe Floris,Karin Leunen,Ellen G. Engelhardt,Annegien Broeks,Emiel J. Th. Rutgers,Gord Glendon,Anna Marie Mulligan,Anna Marie Mulligan,Simon S. Cross,Malcolm W.R. Reed,Anna González-Neira,Jose Ignacio Arias Perez,Elena Provenzano,Carmel Apicella,Melissa C. Southey,Amanda B. Spurdle,Lothar Häberle,Matthias W. Beckmann,Arif B. Ekici,A.K. Dieffenbach,Volker Arndt,Christa Stegmaier,Catriona McLean,Laura Baglietto,Laura Baglietto,Stephen J. Chanock,Jolanta Lissowska,Jolanta Lissowska,Mark E. Sherman,Thomas Brüning,Ute Hamann,Yon-Dschun Ko,Nick Orr,Minouk J. Schoemaker,Alan Ashworth,Veli-Matti Kosma,Vesa Kataja,Jaana M. Hartikainen,Arto Mannermaa,Anthony J. Swerdlow,Graham G. Giles,Hermann Brenner,Hermann Brenner,Peter A. Fasching,Peter A. Fasching,Georgia Chenevix-Trench,Georgia Chenevix-Trench,John L. Hopper,Javier Benitez,Angela Cox,Irene L. Andrulis,Irene L. Andrulis,Diether Lambrechts,Manuela Gago-Dominguez,Fergus J. Couch,Kamila Czene,Stig E. Bojesen,Doug Easton,Marjanka K. Schmidt,Pascal Guénel,Per Hall,Paul D.P. Pharoah,Montserrat Garcia-Closas,Jenny Chang-Claude +97 more
TL;DR: In conclusion, recently identified BC susceptibility loci are not strongly modified by established risk factors and the observed potential interactions require confirmation in independent studies.
Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.
Stefan Nickels,Thérèse Truong,Rebecca Hein,Kristen N. Stevens,Katharina Buck,Sabine Behrens,Ursula Eilber,Martina E. Schmidt,Lothar Häberle,Alina Vrieling,Alina Vrieling,Mia M. Gaudet,Jonine D. Figueroa,Nils Schoof,Amanda B. Spurdle,Anja Rudolph,Peter A. Fasching,Peter A. Fasching,John L. Hopper,Enes Makalic,Daniel F. Schmidt,Melissa C. Southey,Matthias W. Beckmann,Arif B. Ekici,Olivia Fletcher,Lorna Gibson,Isabel dos Santos Silva,Julian Peto,Manjeet K. Humphreys,Jean S Wang,Emilie Cordina-Duverger,Florence Menegaux,Børge G. Nordestgaard,Stig E. Bojesen,Charlotte Lanng,Hoda Anton-Culver,Argyrios Ziogas,Leslie Bernstein,Christina A. Clarke,Christina A. Clarke,Hermann Brenner,Heiko Müller,Volker Arndt,Christa Stegmaier,Hiltrud Brauch,Hiltrud Brauch,Thomas Brüning,Volker Harth,Volker Harth,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Diether Lambrechts,Dominiek Smeets,Patrick Neven,Robert Paridaens,Dieter Flesch-Janys,Nadia Obi,Shan Wang-Gohrke,Fergus J. Couch,Janet E. Olson,Celine M. Vachon,Graham G. Giles,Graham G. Giles,Gianluca Severi,Gianluca Severi,Laura Baglietto,Laura Baglietto,Kenneth Offit,Esther M. John,Esther M. John,Alexander Miron,Irene L. Andrulis,Julia A. Knight,Gord Glendon,Anna Marie Mulligan,Stephen J. Chanock,Jolanta Lissowska,Jianjun Liu,Angela Cox,Helen Cramp,Dan Connley,Sabapathy P. Balasubramanian,Alison M. Dunning,Mitul Shah,Amy Trentham-Dietz,Polly A. Newcomb,Polly A. Newcomb,Linda J. Titus,Kathleen Egan,Elizabeth K. Cahoon,Preetha Rajaraman,Alice J. Sigurdson,Michele M. Doody,Pascal Guénel,Paul D.P. Pharoah,Marjanka K. Schmidt,Per Hall,Doug Easton,Montserrat Garcia-Closas,Roger L. Milne,Jenny Chang-Claude,H. B. Christina Justenhoven,Yon-Dschun Ko,Christian Baisch,Hans-Peter Fischer,Ute Hamann,B. Pesch,Sylvia Rabstein,Anne Lotz,Eija Myöhänen,Helena Kemiläinen,Heather Thorne,Eveline Niedermayr,David D.L. Bowtell,David D.L. Bowtell,Georgia Chenevix-Trench,Georgia Chenevix-Trench,Anna deFazio,Anna deFazio,Dorota M. Gertig,Dorota M. Gertig,A. Green,A. Green,Penny Webb,Penny Webb +126 more
TL;DR: Evidence is provided that the risk of breast cancer associated with some common genetic variants may vary with environmental risk factors, as well as potential interactions between LSP1-rs3817198 and parity and CASP8 and alcohol consumption.
CHEK2*1100delC heterozygosity in women with breast cancer associated with early death, breast cancer-specific death, and increased risk of a second breast cancer.
Maren Weischer,Børge G. Nordestgaard,Paul D.P. Pharoah,Manjeet K. Bolla,Heli Nevanlinna,Laura J. van't Veer,Montserrat Garcia-Closas,John L. Hopper,Per Hall,Irene L. Andrulis,Peter Devilee,Peter A. Fasching,Hoda Anton-Culver,Diether Lambrechts,Maartje J. Hooning,Angela Cox,Graham G. Giles,Graham G. Giles,Barbara Burwinkel,Annika Lindblom,Fergus J. Couch,Arto Mannermaa,Grethe I. Grenaker Alnæs,Esther M. John,Thilo Dörk,Henrik Flyger,Alison M. Dunning,Qin Wang,Taru A. Muranen,Richard van Hien,Jonine D. Figueroa,Melissa C. Southey,Kamila Czene,Julia A. Knight,Rob A. E. M. Tollenaar,Matthias W. Beckmann,Argyrios Ziogas,Marie Rose Christiaens,J. M. Collee,Malcolm W.R. Reed,Gianluca Severi,Gianluca Severi,Frederik Marmé,Sara Margolin,Janet E. Olson,Veli-Matti Kosma,Vessela N. Kristensen,Alexander Miron,Natalia Bogdanova,Mitul Shah,Carl Blomqvist,Annegien Broeks,Mark E. Sherman,Kelly-Anne Phillips,Jingmei Li,Jianjun Liu,Gord Glendon,Caroline Seynaeve,Arif B. Ekici,Karin Leunen,Mieke Kriege,Simon S. Cross,Laura Baglietto,Laura Baglietto,Christof Sohn,Xianshu Wang,Vesa Kataja,Anne Lise Børresen-Dale,Andreas Meyer,Douglas F. Easton,Marjanka K. Schmidt,Stig E. Bojesen +71 more
TL;DR: Among women with estrogen receptor-positive breast cancer, CHEK2*1100delC heterozygosity was associated with a 1.4-fold risk of early death, a 2.6-fold chance of breast cancer-specific death, and a 3.5- fold risk of a second breast cancer.
Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study.
Roger L. Milne,Mia M. Gaudet,Amanda B. Spurdle,Peter A. Fasching,Fergus J. Couch,Javier Benitez,Jose Ignacio Arias Perez,M. Pilar Zamora,Núria Malats,Isabel dos Santos Silva,Lorna Gibson,Olivia Fletcher,Nichola Johnson,Hoda Anton-Culver,Argyrios Ziogas,Jonine D. Figueroa,Louise A. Brinton,Mark E. Sherman,Jolanta Lissowska,John L. Hopper,Gillian S. Dite,Carmel Apicella,Melissa C. Southey,Alice J. Sigurdson,Martha S. Linet,Sara J. Schonfeld,D. Michal Freedman,Arto Mannermaa,Veli-Matti Kosma,Vesa Kataja,Päivi Auvinen,Irene L. Andrulis,Irene L. Andrulis,Irene L. Andrulis,Gord Glendon,Julia A. Knight,Julia A. Knight,Nayana Weerasooriya,Angela Cox,Malcolm Wr Reed,Simon S. Cross,Alison M. Dunning,Shahana Ahmed,Mitul Shah,Hiltrud Brauch,Yon-Dschun Ko,Thomas Brüning,Diether Lambrechts,Joke Reumers,Ann Smeets,Shan Wang-Gohrke,Per Hall,Kamila Czene,Jianjun Liu,Astrid K. Irwanto,Georgia Chenevix-Trench,Helene Holland,kConFab,Aocs,Graham G. Giles,Graham G. Giles,Graham G. Giles,Laura Baglietto,Laura Baglietto,Gianluca Severi,Gianluca Severi,Stig E Bojensen,Børge G. Nordestgaard,Henrik Flyger,Esther M. John,Esther M. John,Dee W. West,Dee W. West,Alice S. Whittemore,Celine M. Vachon,Janet E. Olson,Zachary S. Fredericksen,Matthew L. Kosel,Rebecca Hein,Alina Vrieling,Dieter Flesch-Janys,J Heinz,Matthias W. Beckmann,Katharina Heusinger,Arif B. Ekici,Lothar Haeberle,Manjeet K. Humphreys,Jonathan J. Morrison,Doug Easton,Paul D.P. Pharoah,Montserrat Garcia-Closas,Ellen L. Goode,Jenny Chang-Claude +92 more
TL;DR: The relative risks for breast cancer associated with the common susceptibility variants identified to date do not appear to vary across women with different reproductive histories or body mass index (BMI); the assumption of multiplicative combined effects for these established genetic and other risk factors in risk prediction models appears justified.
11q13 is a susceptibility locus for hormone receptor positive breast cancer
Diether Lambrechts,Thérèse Truong,Christina Justenhoven,Manjeet K. Humphreys,Jean Wang,John L. Hopper,Gillian S. Dite,Carmel Apicella,MC Southey,Marjanka K. Schmidt,Annegien Broeks,Sten Cornelissen,Richard van Hien,Elinor J. Sawyer,Ian Tomlinson,Michael J. Kerin,Nicola Miller,Roger L. Milne,M. Pilar Zamora,Jose Ignacio Arias Perez,Javier Benitez,Ute Hamann,Yon Ko,Thomas Brüning,Jenny Chang-Claude,Ursel Eilber,Rebecca Hein,Stefan Nickels,Dieter Flesch-Janys,Shan Wang-Gohrke,Esther M. John,Alexander Miron,Robert Winqvist,Katri Pylkäs,Arja Jukkola-Vuorinen,Mervi Grip,Georgia Chenevix-Trench,Jonathan Beesley,Xiaoqing Chen,kConFab Investigators,Florence Menegaux,Emilie Cordina-Duverger,Chen-Yang Shen,Jyh Cherng Yu,Pei Ei Wu,Ming-Feng Hou,Irene L. Andrulis,Teresa Selander,Gord Glendon,Anna Marie Mulligan,Hoda Anton-Culver,Argyrios Ziogas,Kenneth Muir,Artitaya Lophatananon,Suthee Rattanamongkongul,Puttisak Puttawibul,Michael Jones,Nick Orr,Alan Ashworth,Anthony J. Swerdlow,Gianluca Severi,Laura Baglietto,Graham G. Giles,Graham G. Giles,Melissa C. Southey,Federik Marme,Andreas Schneeweiss,Christof Sohn,Barbara Burwinkel,Barbara Burwinkel,Betül T. Yesilyurt,Patrick Neven,Robert Paridaens,Hans Wildiers,Hermann Brenner,Heiko Müller,Volker Arndt,Christa Stegmaier,Alfons Meindl,Sarah Schott,Claus R. Bartram,Rita K. Schmutzler,Angela Cox,Ian W. Brock,Graeme Elliott,Simon S. Cross,Peter A. Fasching,Ruediger Schulz-Wendtland,Arif B. Ekici,Matthias W. Beckmann,Olivia Fletcher,Nichola Johnson,Isabel dos Santos Silva,Julian Peto,Heli Nevanlinna,Taru A. Muranen,Kristiina Aittomäki,Carl Blomqvist,Thilo Dörk,Peter Schürmann,Michael Bremer,Peter Hillemanns,Natalia Bogdanova,Natalia Antonenkova,Yuri I. Rogov,Johann H. Karstens,Elza Khusnutdinova,Marina Bermisheva,Darya Prokofieva,Shamil Gancev,Anna Jakubowska,Jan Lubinski,Katarzyna Jaworska,Katarzyna Durda,Børge G. Nordestgaard,Stig E. Bojesen,Charlotte Lanng,Arto Mannermaa,Vesa Kataja,Veli-Matti Kosma,Jaana M. Hartikainen,Paolo Radice,Paolo Peterlongo,Siranoush Manoukian,Loris Bernard,Fergus J. Couch,Janet E. Olson,Xianshu Wang,Zachary S. Fredericksen,Grethe I. Grenaker Alnæs,Vessela N. Kristensen,Vessela N. Kristensen,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Peter Devilee,Robert A.E.M. Tollenaar,Caroline M. Seynaeve,Maartje J. Hooning,Montserrat Garcia-Closas,Stephen J. Chanock,Jolanta Lissowska,Mark E. Sherman,Per Hall,Jianjun Liu,Kamila Czene,Daehee Kang,Keun-Young Yoo,Dong Young Noh,Annika Lindblom,Sara Margolin,Alison M. Dunning,Paul D.P. Pharoah,Douglas F. Easton,Pascal Guénel,Hiltrud Brauch,Hiltrud Brauch +155 more
TL;DR: The strongest evidence was obtained for rs614367, located on 11q13, which was specific to estrogen receptor (ER)‐positive disease and strongest for ER plus progesterone receptor (PR)‐ positive breast cancer, whereas the associations for the other three loci did not differ by tumor subtype.