Arif B. Ekici
University of Erlangen-Nuremberg
356 Papers
1.5K Citations
Arif B. Ekici is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Medicine & Breast cancer. The author has an hindex of 67, co-authored 316 publications. Previous affiliations of Arif B. Ekici include University of Regensburg & University of California, Los Angeles.
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Papers
Exome Pool-Seq in neurodevelopmental disorders.
Bernt Popp,Arif B. Ekici,Christian Thiel,Juliane Hoyer,Antje Wiesener,Cornelia Kraus,André Reis,Christiane Zweier +7 more
TL;DR: With a detection rate of 28%, Exome Pool-Seq achieves comparable results to individual exome analyses but reduces costs by >85%.
Chromatin-Remodeling-Factor ARID1B Represses Wnt/β-Catenin Signaling
Georgia Vasileiou,Arif B. Ekici,Steffen Uebe,Christiane Zweier,Juliane Hoyer,Hartmut Engels,Jürgen Behrens,André Reis,Michel V. Hadjihannas +8 more
TL;DR: The data suggest that aberrations in chromatin-remodeling factors,such as ARID1B, might contribute to neurodevelopmental abnormalities and cancer through deregulation of developmental and oncogenic pathways, such as the Wnt/β-catenin signaling pathway.
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Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy
Krzysztof Kiryluk,Elena Sanchez-Rodriguez,Xu-jie Zhou,Francesca Zanoni,Lili Liu,Nikol Mladkova,Atlas Khan,Maddalena Marasa,Jun Zhang,Olivia Balderes,Simone Sanna-Cherchi,Andrew S. Bomback,Pietro A. Canetta,Gerald B. Appel,Jai Radhakrishnan,Hernán Trimarchi,Ben Sprangers,Daniel C. Cattran,Heather N. Reich,York Pei,Pietro Ravani,Krešimir Galešić,Dita Maixnerova,Vladimir Tesar,Bénédicte Stengel,Marie Metzger,Guillaume Canaud,Nicolas Maillard,François Berthoux,Laureline Berthelot,Evangeline Pillebout,Renato C. Monteiro,Raoul D. Nelson,Robert J. Wyatt,William E. Smoyer,John Monahan,Al-Akash Samhar,Guillermo Hidalgo,Alejandro Quiroga,Patricia L. Weng,Raji Sreedharan,David T. Selewski,Keefe Davis,Mahmoud Kallash,Tetyana I. Vasylyeva,Michelle N. Rheault,Aftab S. Chishti,Daniel Ranch,Scott E. Wenderfer,Dmitry V. Samsonov,Donna J. Claes,Oleh Akchurin,Dimitrios S. Goumenos,Maria Stangou,Judit Nagy,Tibor Kovács,Enrico Fiaccadori,Antonio Amoroso,Cristina Barlassina,Daniele Cusi,Lucia Del Vecchio,Giovanni Giorgio Battaglia,Monica Bodria,Emanuela Boer,Luisa Bono,Giuliano Boscutti,Gianluca Caridi,Francesca Lugani,Gian Marco Ghiggeri,Rosanna Coppo,Licia Peruzzi,Vittoria Esposito,Ciro Esposito,Sandro Feriozzi,Rosaria Polci,Giovanni M. Frascà,Marco Galliani,Maurizio Garozzo,Adele Mitrotti,Loreto Gesualdo,Simona Granata,Gianluigi Zaza,Francesco Londrino,Riccardo Magistroni,Isabella Pisani,Andrea Magnano,Carmelita Marcantoni,Piergiorgio Messa,Renzo Mignani,Antonello Pani,Claudio Ponticelli,Dario Roccatello,Maurizio Salvadori,Erica Salvi,Domenico Santoro,Guido Gembillo,Silvana Savoldi,Donatella Spotti,Pasquale Zamboli,Claudia Izzi,Federico Alberici,Elisa Delbarba,Michael A. Florczak,Natalia Krata,Krzysztof Mucha,Leszek Paczek,Stanisław Niemczyk,Barbara Moszczuk,Małgorzata Pańczyk-Tomaszewska,Małgorzata Mizerska-Wasiak,Agnieszka Perkowska-Ptasińska,T Baczkowska,Magdalena Durlik,Krzysztof Pawlaczyk,Przemysław Sikora,Marcin Zaniew,Dorota Kaminska,Magdalena Krajewska,Izabella Kuźmiuk-Glembin,Zbigniew Heleniak,Barbara Bułło-Piontecka,Tomasz Liberek,Alicja Dębska-Ślizień,Tomasz Hryszko,Anna Materna-Kiryluk,Monika Miklaszewska,Maria Szczepańska,Katarzyna Dyga,Edyta Machura,Katarzyna Siniewicz-Luzeńczyk,Monika Pawlak-Bratkowska,Marcin Tkaczyk,Dariusz Runowski,Norbert Kwella,Dorota Drozdz,Ireneusz Habura,Florian Kronenberg,Larisa Prikhodina,David A. van Heel,Bertrand Fontaine,Chris Cotsapas,Cisca Wijmenga,Andre Franke,Vito Annese,Peter K. Gregersen,Sreeja Parameswaran,Matthew T. Weirauch,Leah C. Kottyan,John B. Harley,Hiroshi Suzuki,Ichiei Narita,Shin Goto,Hajeong Lee,Dong Ki Kim,Young S. Kim,Jin Ho Park,Belong Cho,Murim Choi,Ans van Wijk,Ana Huerta,Elisabet Ars,José Ballarín,Sigrid Lundberg,Bruno Vogt,Laila-Yasmin Mani,Yasar Caliskan,Jonathan Barratt,Thilini Abeygunaratne,Philip A. Kalra,Daniel Gale,Ulf Panzer,Thomas Rauen,Jürgen Floege,Pascal Schlosser,Arif B. Ekici,Kai-Uwe Eckardt,Nan Chen,Jingyuan Xie,Richard P. Lifton,Ruth J. F. Loos,Eimear E. Kenny,Iuliana Ionita-Laza,Anna Köttgen,Bruce A. Julian,Jan Novak,Francesco Scolari,Long Zhang,Ali G. Gharavi +187 more
TL;DR: A genome-wide association study of 10,146 kidney-biopsy-diagnosed IgAN cases and 28,751 controls and a comprehensive functional annotation analysis of candidate causal genes observed convergence of biological candidates on a common set of inflammatory signaling pathways and cytokine ligand–receptor pairs, prioritizing potential new drug targets.
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Fatty acid elongation in yeast Biochemical characteristics of the enzyme system and isolation of elongation-defective mutants
Franziska Dittrich,Dirk Zajonc,Kathrin Hühne,Ursula Hoja,Arif B. Ekici,Eva Greiner,Hans Klein,Jörg Hofmann,Jean-Jacques Bessoule,Petra Sperling,Eckhart Schweizer +10 more
TL;DR: Yeast contains either two different elongation systems, or that the respective mutation interferes differentially with medium-chain and long-chain fatty acid elongation, and VLCFA synthesis exhibits a higher processivity in vivo than in the cell homogenate.
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Myeloperoxidase Modulates Inflammation in Generalized Pustular Psoriasis and Additional Rare Pustular Skin Diseases.
Stefan Haskamp,Heiko Bruns,Madelaine Hahn,Markus H. Hoffmann,Anne Gregor,Sabine Löhr,Jonas Hahn,Christine Schauer,Mark Ringer,Cindy Flamann,Benjamin Frey,Adam Lesner,Christian Thiel,Arif B. Ekici,Stephan von Hörsten,Gunter Aßmann,Claudia Riepe,Maximilien Euler,Knut Schäkel,Sandra Philipp,Jörg C. Prinz,Rotraut Mößner,Florina Kersting,Michael Sticherling,Abdelaziz Sefiani,Jaber Lyahyai,Wiebke Sondermann,Vinzenz Oji,Peter Schulz,Dagmar Wilsmann-Theis,Heinrich Sticht,Georg Schett,André Reis,Steffen Uebe,Silke Frey,Ulrike Hüffmeier +35 more
TL;DR: The implicate MPO as an inflammatory modulator in humans that regulates protease activity and NET formation and modifies efferocytosis and affected pathways represent attractive targets for inducing resolution of inflammation in neutrophil-mediated skin diseases.
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