Ari Hirvonen
Finnish Institute of Occupational Health
198 Papers
5.3K Citations
Ari Hirvonen is an academic researcher from Finnish Institute of Occupational Health. The author has contributed to research in topics: Genotype & Lung cancer. The author has an hindex of 66, co-authored 196 publications. Previous affiliations of Ari Hirvonen include Orion Corporation.
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Papers
The hypermethylation of the O6-methylguanine-DNA methyltransferase gene promoter in gliomas—correlation with array comparative genome hybridization results and IDH1 mutation
Katja Tuononen,Olli Tynninen,Olli Tynninen,Virinder Kaur Sarhadi,Anne Tyybäkinoja,Mikael Lindlöf,Miia Antikainen,Juha Näpänkangas,Ari Hirvonen,Hanna Mäenpää,Anders Paetau,Anders Paetau,Sakari Knuutila,Sakari Knuutila +13 more
TL;DR: The results suggest that MGMT promoter methylation, analyzed by pyrosequencing, is a frequent event in oligodendroglial tumors, and it correlates with IDH1 mutation and 19q loss in gliomas.
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The genotypes and methylation of MAO genes as factors behind smoking behavior.
TL;DR: Smoking behavior seems to be related to the genetic and epigenetic profile of MAO genes, with considerable individual and sex-related differences.
17
Genetic susceptibility to asbestos-related fibrotic pleuropulmonary changes
Mari K Kukkonen,S. Hämäläinen,Simo Kaleva,Tapio Vehmas,Matti S. Huuskonen,Panu Oksa,Harri Vainio,Päivi Piirilä,Ari Hirvonen +8 more
TL;DR: The data suggest that inherited detoxification capacity may affect the development and severity of asbestos and smoking-related nonmalignant pulmonary changes.
15
•Journal Article
XRCC1 rs25487 polymorphism predicts the survival of patients after postoperative radiotherapy and adjuvant chemotherapy for breast cancer.
TL;DR: The XRCC1 rs25487 genotype may predict the outcome of postoperative radiotherapy and adjuvant chemotherapy in breast cancer.
14
Protein adducts as biomarkers of exposure to aromatic diisocyanates in workers manufacturing polyurethane (PUR) foam
Kirsi Säkkinen,Jarkko Tornaeus,Antti Hesso,Ari Hirvonen,Harri Vainio,Hannu Norppa,Christina Rosenberg +6 more
TL;DR: An important outcome of the study was that no amine-related adducts were detected in globin samples from TDI- or MDI-exposed workers, alleviating concerns that TDI orMDI might pose a carcinogenic hazard.
14