Ari Hirvonen
Finnish Institute of Occupational Health
198 Papers
5.3K Citations
Ari Hirvonen is an academic researcher from Finnish Institute of Occupational Health. The author has contributed to research in topics: Genotype & Lung cancer. The author has an hindex of 66, co-authored 196 publications. Previous affiliations of Ari Hirvonen include Orion Corporation.
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Papers
Metabolic gene polymorphisms and lung cancer risk in non-smokers. An update of the GSEC study.
Sara Raimondi,Paolo Boffetta,Sisko Anttila,Jürgen Brockmöller,Dorota Butkiewicz,Ingolf Cascorbi,Margie L. Clapper,Tommaso A. Dragani,Seymour Garte,Andre Gsur,Gerald Haidinger,Ari Hirvonen,Magnus Ingelman-Sundberg,Ivan Kalina,Qing Lan,Vera Piera Leoni,Loic Le Marchand,Stephanie J. London,Monica Neri,Andrew C. Povey,Agneta Rannug,Edyta Reszka,David Ryberg,Angela Risch,Marjorie Romkes,Alberto Ruano-Ravina,Bernadette Schoket,Monica Spinola,Haruhiko Sugimura,Xifeng Wu,Emanuela Taioli +30 more
TL;DR: Findings that CYP1A1Ile462Val polymorphism may play a role in lung carcinogenesis in Caucasian non-smokers are confirmed.
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Polymorphisms in the estrogen receptor-alpha gene and breast cancer risk.
Hee Joon Kang,Sung Won Kim,Hee Joung Kim,Soo Jung Ahn,Ji Yeon Bae,Sue Kyung Park,Daehee Kang,Ari Hirvonen,Kuk Jin Choe,Dong Young Noh +9 more
TL;DR: Only one of the allelic variants of ERalpha gene was found in study subjects; the (C(975)G) change was present in half of the study subjects and had no direct effect in individual breast cancer risk, but was positively associated with tumor PR and ER expression and negatively associated with p53 expression.
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Combined effect of glutathione S-transferase M1 and T1 genotypes on bladder cancer risk.
Seung Joon Lee,Soo Hun Cho,Sue Kyung Park,Soo Woong Kim,Moon Soo Park,Han Yong Choi,Ji Yeob Choi,Sang Yoon Lee,Hyoung June Im,Jae Yong Kim,Ki Jung Yoon,Hwang Choi,Sang-Goo Shin,Tae Won Park,Nathaniel Rothman,Ari Hirvonen,Daehee Kang +16 more
TL;DR: There was a statistically significant multiple interaction between GSTM1 and GSTT1 genotype for risk of bladder cancer (P=0.04), and the risk associated with the concurrent lack of both of the genes was greater than the product of risk in men with GSTM 1 null/GSTT1 present or GSTM2 present/GstT1 null genotype combinations.
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Influence of GSTM1, GSTT1, GSTP1, and EPHX gene polymorphisms on DNA adduct level and HPRT mutant frequency in coke-oven workers
Cristina Viezzer,Hannu Norppa,Erminio Clonfero,G Gabbani,Giuseppe Mastrangelo,Ari Hirvonen,Lucia Celotti +6 more
TL;DR: It is indicated that homozygous deletion of GSTM1 results in an increased sensitivity to genotoxic PAHs in tobacco smoke, which is seen as an increase in aromatic DNA adducts in blood mononuclear cells.
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hOGG1 Ser326Cys polymorphism and breast cancer risk among Asian women.
Ji Yeob Choi,Nobuyuki Hamajima,Kazuo Tajima,Keun-Young Yoo,Kyung Sik Yoon,Sue Kyung Park,Sook Un Kim,Kyung Mu Lee,Dong-Young Noh,Se Hyun Ahn,Kuk Jin Choe,Wonshik Han,Ari Hirvonen,Daehee Kang +13 more
TL;DR: It is suggested that hOGG1 Ser326Cys polymorphism is unlikely to play a modifying role in individual susceptibility to breast cancer among Asian women, and no statistically significant associations between the genotypes and breast cancer risk were observed.
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