Argiris Efstratiadis
Academy of Athens
10 Papers
9 Citations
Argiris Efstratiadis is an academic researcher from Academy of Athens. The author has contributed to research in topics: Carcinogenesis & Transgene. The author has an hindex of 6, co-authored 10 publications. Previous affiliations of Argiris Efstratiadis include Columbia University Medical Center.
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Papers
CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia
Silvia Buonamici,Thomas Trimarchi,Maria Grazia Ruocco,Linsey Reavie,Séverine Cathelin,Brenton G. Mar,Apostolos Klinakis,Yevgeniy Lukyanov,Jen-Chieh Tseng,Filiz Sen,Eric A. Gehrie,Mengling Li,Elizabeth W. Newcomb,Jiri Zavadil,Daniel Meruelo,Martin Lipp,Sherif Ibrahim,Argiris Efstratiadis,David Zagzag,Jonathan S. Bromberg,Michael L. Dustin,Iannis Aifantis +21 more
TL;DR: It is shown that the chemokine receptor CCR7 is the essential adhesion signal required for the targeting of leukaemic T-cells into the CNS and targeted inhibition of CNS involvement in T-ALL could potentially decrease the intensity of CNS-targeted therapy, thus reducing its associated short- and long-term complications.
Role of IGF signaling in olfactory sensory map formation and axon guidance
Jonathan Scolnick,Kai Cui,Cynthia Duggan,Shouhong Xuan,Xiao-bing Yuan,Argiris Efstratiadis,John Ngai +6 more
TL;DR: It is demonstrated that insulin-like growth factor (IGF) signaling is required for sensory innervation of the lateral olfactory bulb and that IGF is a chemoattractant for axon growth cones.
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Notch, Myc and breast cancer.
TL;DR: A combination of genetic and molecular data demonstrated that Myc is a direct transcriptional target of Notch1 participating as an indispensable downstream effector in N1IC-induced tumorigenic action.
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Therapeutic Effects of an Anti-Myc Drug on Mouse Pancreatic Cancer
Dimitris Stellas,Matthias Szabolcs,Sanjay Koul,Zhe Li,Alexander Polyzos,Constantinos Anagnostopoulos,Zoe Cournia,Constantin Tamvakopoulos,Apostolos Klinakis,Argiris Efstratiadis +9 more
TL;DR: These results provide strong justification for eventual clinical evaluation of anti-Myc drugs as potential chemotherapeutic agents for the treatment of PDA.
Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer.
Ekaterina Mameishvili,Ioannis Serafimidis,Sara Iwaszkiewicz,Mathias Lesche,Mathias Lesche,Susanne Reinhardt,Nora Bölicke,Nora Bölicke,Maren Büttner,Dimitris Stellas,Adriana Papadimitropoulou,Matthias Szabolcs,Konstantinos Anastassiadis,Andreas Dahl,Fabian J. Theis,Argiris Efstratiadis,Anthony Gavalas +16 more
TL;DR: It is demonstrated genetically that ablation of Aldh1b1 completely abrogates tumor development in a mouse model of KrasG12D-induced pancreatic cancer, suggesting that these cells play a key role in the disease and potentially constitute a therapeutic target for Pancreas cancer.
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