Ardem Patapoutian
Howard Hughes Medical Institute
155 Papers
1K Citations
Ardem Patapoutian is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Mechanotransduction & Transient receptor potential channel. The author has an hindex of 75, co-authored 133 publications. Previous affiliations of Ardem Patapoutian include University of California, San Francisco & Scripps Health.
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Papers
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
Bertrand Coste,Jayanti Mathur,Manuela Schmidt,Taryn J. Earley,Sanjeev S. Ranade,Matt Petrus,Adrienne E. Dubin,Ardem Patapoutian,Ardem Patapoutian +8 more
TL;DR: Two genes that encode proteins, Piezo1 and Piezo2, are identified, which are required for mechanically stimulated cation conductance in these cells and in cultured dorsal root ganglion neurons, and it is proposed that Piezos are components of MA cation channels.
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
Gina M. Story,Andrea M. Peier,Alison J. Reeve,Samer R. Eid,Johannes Mosbacher,Todd R. Hricik,Taryn J. Earley,Anne C. Hergarden,David Andersson,Sun Wook Hwang,Peter McIntyre,Timothy Jegla,Stuart Bevan,Ardem Patapoutian,Ardem Patapoutian +14 more
TL;DR: The characterization of ANKTM1 is described, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8, which is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM 8.
2.5K
A TRP Channel that Senses Cold Stimuli and Menthol
Andrea M. Peier,Aziz Moqrich,Anne C. Hergarden,Alison J. Reeve,David Andersson,Gina M. Story,Taryn J. Earley,Ilaria Dragoni,Peter McIntyre,Stuart Bevan,Ardem Patapoutian,Ardem Patapoutian +11 more
TL;DR: This work describes the cloning and characterization of TRPM8, a distant relative of VR1 that is specifically expressed in a subset of pain- and temperature-sensing neurons and implicates an expanded role for this family of ion channels in somatic sensory detection.
2.3K
Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin
Michael Bandell,Gina M. Story,Sun Wook Hwang,Veena Viswanath,Samer R. Eid,Matt Petrus,Taryn J. Earley,Ardem Patapoutian,Ardem Patapoutian +8 more
TL;DR: It is demonstrated that TRPA1 activation elicits a painful sensation and provide a potential molecular model for why noxious cold can paradoxically be perceived as burning pain.
1.8K
Large-scale analysis of the human and mouse transcriptomes
Andrew I. Su,Michael P. Cooke,Keith A. Ching,Yaron Hakak,John R. Walker,Tim Wiltshire,Anthony P. Orth,Raquel Vega,Lisa M. Sapinoso,Aziz Moqrich,Ardem Patapoutian,Garret M. Hampton,Peter G. Schultz,Peter G. Schultz,John B. Hogenesch +14 more
TL;DR: This work generated and analyzed gene expression from 91 human and mouse samples across a diverse array of tissues, organs, and cell lines to reveal insights into molecular and physiological gene function, mechanisms of transcriptional regulation, disease etiology, and comparative genomics.