Aravin N. Sukumar
University of Toronto
5 Papers
4 Citations
Aravin N. Sukumar is an academic researcher from University of Toronto. The author has contributed to research in topics: Enos & Angiogenesis. The author has an hindex of 3, co-authored 4 publications. Previous affiliations of Aravin N. Sukumar include St. Michael's Hospital.
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Papers
Angiogenic patterning by STEEL, an endothelial-enriched long noncoding RNA
H. S. Jeffrey Man,Aravin N. Sukumar,Gabrielle C. Lam,Paul J. Turgeon,Matthew Yan,Kyung Ha Ku,Michelle K. Dubinsky,J.J. David Ho,Jenny Wang,Sunit Das,Nora Mitchell,Peter Oettgen,Michael V. Sefton,Philip A. Marsden +13 more
TL;DR: A role for EC-enriched lncRNAs in the phenotypic adaptation of ECs to both body position and hemodynamic forces is identified and a role for spliced-transcript endothelial-en enriched lncRNA (STEEL) in angiogenic potential, macrovascular/microvascular identity, and shear stress responsiveness is defined.
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Gene Expression Analysis of Endothelial Cells Exposed to Shear Stress Using Multiple Parallel-plate Flow Chambers
H. S. Jeffrey Man,Aravin N. Sukumar,Kyung Ha Ku,Michelle K. Dubinsky,Noeline Subramaniam,Philip A. Marsden +5 more
TL;DR: Key adaptations in the set-up for laminar flow as presented here include a large, dedicated environment to house concurrent flow circuits, the monitoring of flow rates in real-time, and the inclusion of an exogenous reference RNA for the normalization of quantitative real- time PCR data.
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In Vivo Function of Flow-Responsive Cis -DNA Elements of the Endothelial Nitric Oxide Synthase Gene: A Role for Chromatin-Based Mechanisms.
Kyung Ha Ku,Michelle K. Dubinsky,Aravin N. Sukumar,Noeline Subramaniam,Manon Y M Feasson,Ranju Nair,Eileen Tran,Brent M. Steer,Britta J. Knight,Philip A. Marsden +9 more
TL;DR: The eNOS (endothelial nitric oxide synthase) gene is an endothelial cell (EC) specific gene predominantly expressed in medium-to large-sized arteries where ECs experience atheroprotective lamin...
Long noncoding RNA GATA2-AS1 augments endothelial hypoxia inducible factor 1-α induction and regulates hypoxic signaling
H. S. Jeffrey Man,Noeline Subramaniam,Tiana Downs,Aravin N. Sukumar,Aninda Saha,Ranju Nair,Lucy Chen,Daniel Teitelbaum,Paul J. Turgeon,Kyung Ha Ku,Eileen Tran,Marc de Perrot,Philip A. Marsden +12 more
TL;DR: In this paper , an abundant, cytoplasmic, and EC-enriched lncRNA, GATA2-AS1, that is divergently transcribed from the EC-enhanced developmental regulator was found to contribute to the "HIF switch" and augments HIF1α/HIF2-α balance.
Epigenetics of Cardiovascular Disease: A New ‘Beat' in Coronary Artery Disease
Paul J. Turgeon,Aravin N. Sukumar,Philip A. Marsden +2 more
- 25 Mar 2014
TL;DR: This review is an introduction to epigenetic function and CVD, with a focus on endothelial cell biology, and highlights emerging concepts on epigenetic gene regulation that are highly relevant to atherosclerosis and coronary artery disease.