Aram B. Cholanians
University of Arizona
10 Papers
19 Citations
Aram B. Cholanians is an academic researcher from University of Arizona. The author has contributed to research in topics: MDMA & Monoamine neurotransmitter. The author has an hindex of 7, co-authored 9 publications. Previous affiliations of Aram B. Cholanians include Boston Children's Hospital.
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Papers
The Rodent Forced Swim Test Measures Stress-Coping Strategy, Not Depression-like Behavior.
TL;DR: Evidence is reviewed that argues a more thoughtful consideration of the FST, and more precise terminology, would benefit the study of stress and disorders characterized by altered response to stress, which include but are not limited to depression.
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Modulating NRF2 in Disease: Timing Is Everything.
Matthew Dodson,Montserrat Rojo de la Vega,Aram B. Cholanians,Cody J. Schmidlin,Eli Chapman,Donna D. Zhang +5 more
TL;DR: The role of NRF2 in cancer, neurodegeneration, and diabetes as well as cardiovascular, kidney, and liver disease is discussed, with a special emphasis onNRF2-based therapeutics, including those that have made it into clinical trials.
From the Cover: Arsenic Induces Accumulation of α-Synuclein: Implications for Synucleinopathies and Neurodegeneration
Aram B. Cholanians,Andy Phan,Eric J. Ditzel,Todd D. Camenisch,Serrine S. Lau,Terrence J. Monks +5 more
TL;DR: The findings suggest that susceptible individuals may be at higher risk of developing synucleinopathies and/or neurodegeneration due to environmental As exposure and possibly leads to compensatory mechanisms leading to an increase in TH expression.
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Increased O-GlcNAcylation of SNAP29 Drives Arsenic-Induced Autophagic Dysfunction.
Matthew Dodson,Pengfei Liu,Tao Jiang,Andrew J. Ambrose,Gang Luo,Montserrat Rojo de la Vega,Aram B. Cholanians,Pak Kin Wong,Eli Chapman,Donna D. Zhang +9 more
TL;DR: It is shown that arsenic blocks autophagy by preventing autophagosome-lysosome fusion, and a mechanism by which low levels of arsenic perturb proteostasis through inhibition of SNARE complex formation is revealed, providing a possible therapeutic target for disease intervention in the more than 200 million people exposed to unsafe Levels of arsenic.
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Serotonin Reuptake Transporter Deficiency Modulates the Acute Thermoregulatory and Locomotor Activity Response to 3,4-(±)-Methylenedioxymethamphetamine, and Attenuates Depletions in Serotonin Levels in SERT-KO Rats
Lucina E. Lizarraga,Andy Phan,Aram B. Cholanians,Joseph M. Herndon,Serrine S. Lau,Terrence J. Monks +5 more
TL;DR: SERT deficiency modulated MDMA-mediated thermogenesis, hyperactivity and neurotoxicity in KO rats, confirming that the SERT is essential for the manifestation of the acute and long-term toxicities of MDMA.
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