Anujan Ramesh
University of Massachusetts Amherst
20 Papers
14 Citations
Anujan Ramesh is an academic researcher from University of Massachusetts Amherst. The author has contributed to research in topics: Immunotherapy & Macrophage. The author has an hindex of 7, co-authored 13 publications. Previous affiliations of Anujan Ramesh include University of Massachusetts Boston.
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Papers
A designer self-assembled supramolecule amplifies macrophage immune responses against aggressive cancer
Ashish Kulkarni,Ashish Kulkarni,Vineethkrishna Chandrasekar,Siva Kumar Natarajan,Anujan Ramesh,Prithviraj Pandey,Jayashree Nirgud,Harshangda Bhatnagar,Driti Ashok,Amrendra Kumar Ajay,Shiladitya Sengupta,Shiladitya Sengupta,Shiladitya Sengupta +12 more
TL;DR: A supramolecular assembly consisting of amphiphiles inhibiting the colony stimulating factor 1 receptor and SIRPα receptors on macrophages significantly enhances antitumour and antimetastatic efficacies in two aggressive animal models of melanoma and breast cancer.
CSF1R- and SHP2-Inhibitor-Loaded Nanoparticles Enhance Cytotoxic Activity and Phagocytosis in Tumor-Associated Macrophages.
TL;DR: It is reported that self‐assembled dual‐inhibitor‐loaded nanoparticles (DNTs) target M2 macrophages and simultaneously inhibit CSF1R and SHP2 pathways, and suboptimal dose administration of DNTs in highly aggressive breast cancer and melanoma mouse models show enhanced anti‐tumor efficacy without any toxicity.
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Dual inhibition of CSF1R and MAPK pathways using supramolecular nanoparticles enhances macrophage immunotherapy
TL;DR: The data suggests that concurrent, vertical inhibition of multiple intracellular kinase signaling pathways is important for repolarization of M2 macrophages to M1 phenotype, and by utilizing dual-inhibitor loaded supramolecular nanoparticles, further increase the ability to produce more M1 macrophage as compared to M2macrophages in the tumor microenvironment.
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A Nitric Oxide (NO) Nanoreporter for Noninvasive Real-Time Imaging of Macrophage Immunotherapy
TL;DR: A first‐of‐its‐kind NO nanoreporter tool is reported that can be used as an activatable imaging agent to monitor macrophage immunotherapy response in real time and sustained inhibition of colony stimulating factor 1 receptor using a CSF1R inhibitor–NO‐NR system leads to enhanced efficacy and better imaging signal.
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Protein Corona Formation on Lipid Nanoparticles Negatively Affects the NLRP3 Inflammasome Activation.
Maharshi Debnath,James Forster,Anujan Ramesh,Ashish Kulkarni +3 more
TL;DR: The inhibiting effect of the absorbed proteins on the LNPs on the NLRP3 inflammasome activation, a key intracellular protein complex that modulates several inflammatory responses, is studied and reported.
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