Antti Lauerma
University of Helsinki
134 Papers
751 Citations
Antti Lauerma is an academic researcher from University of Helsinki. The author has contributed to research in topics: Medicine & Atopic dermatitis. The author has an hindex of 36, co-authored 122 publications. Previous affiliations of Antti Lauerma include Helsinki University Central Hospital & University of Osnabrück.
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Papers
Toll-Like Receptor Activation during Cutaneous Allergen Sensitization Blocks Development of Asthma through IFN-Gamma-Dependent Mechanisms
Rita Haapakoski,Piia Karisola,Nanna Fyhrquist,Terhi Savinko,Sari Lehtimäki,Henrik Wolff,Antti Lauerma,Harri Alenius +7 more
TL;DR: Findings support the hygiene hypothesis and pinpoint the importance of dermal microbiome in the development of allergy and asthma by modulating the asthmatic response by skewing the Th1/Th2 balance toward Th1 by stimulating the production of IFN-γ.
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Transforming growth factor-beta/Smad3 signalling regulates inflammatory responses in a murine model of contact hypersensitivity.
TL;DR: This work has shown that the Smad proteins, which are intracellular TGF‐β signal transducers, mediate most actions of T GF‐β.
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Absence of CCR4 exacerbates skin inflammation in an oxazolone-induced contact hypersensitivity model.
Sari Lehtimäki,Sari Tillander,Anne Puustinen,Sampsa Matikainen,Tuula A. Nyman,Nanna Fyhrquist,Terhi Savinko,Marja-Leena Majuri,Henrik Wolff,Harri Alenius,Antti Lauerma,Antti Lauerma +11 more
TL;DR: It is demonstrated that the absence of CCR4 results in enhanced secondary immune response during allergic skin inflammation, and the number of CD3+CD4+ cells in C CR4-/- mice remained high longer during the sensitization phase and increased more rapidly during the elicitation phase compared with WT mice.
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Epicutaneous natural rubber latex sensitization induces T helper 2-type dermatitis and strong prohevein-specific IgE response.
Maili Lehto,Minna Koivuluhta,Guoying Wang,Iman Amghaiab,Marja-Leena Majuri,Kai Savolainen,Kristiina Turjanmaa,Henrik Wolff,Timo Reunala,Antti Lauerma,Timo Palosuo,Harri Alenius +11 more
TL;DR: It is demonstrated that epicutaneous sensitization with natural rubber latex induces T helper 2-dominated dermal inflammation and strong immunoglobulin E response in this murine model ofnatural rubber latex induced protein contact dermatitis.
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The temporal and spatial dynamics of Foxp3+ Treg cell-mediated suppression during contact hypersensitivity responses in a murine model.
Sari Lehtimäki,Terhi Savinko,Katharina Lahl,Tim Sparwasser,Henrik Wolff,Antti Lauerma,Harri Alenius,Nanna Fyhrquist +7 more
TL;DR: The results show that endogenous Foxp3+ Treg cell function is important during the sensitization and resolution phases, but their depletion just before elicitation does not have an effect on the CHS response during the first 24 hours after elicitation.
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