Antti Kivelä
University of Helsinki
45 Papers
241 Citations
Antti Kivelä is an academic researcher from University of Helsinki. The author has contributed to research in topics: Medicine & Vascular endothelial growth factor. The author has an hindex of 23, co-authored 43 publications. Previous affiliations of Antti Kivelä include Helsinki University Central Hospital & University of Eastern Finland.
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Papers
Characterization of CA XIII, a Novel Member of the Carbonic Anhydrase Isozyme Family
Jonna M. Lehtonen,Bairong Shen,Mauno Vihinen,Angela Casini,Andrea Scozzafava,Claudiu T. Supuran,Anna-Kaisa Parkkila,Juha Saarnio,Antti Kivelä,Abdul Waheed,William S. Sly,Seppo Parkkila,Seppo Parkkila +12 more
TL;DR: The predicted amino acid sequence, structural model, distribution, and activity data suggest that CA XIII represents a novel enzyme, which may play important physiological roles in several organs.
267
Adenoviral intramyocardial VEGF-DΔNΔC gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up.
Juha Hartikainen,Iiro Hassinen,Antti Hedman,Antti Kivelä,Antti Saraste,Juhani Knuuti,Minna Husso,Hanna Mussalo,Marja Hedman,Tuomas T. Rissanen,Pyry I. Toivanen,Tommi Heikura,Joseph L. Witztum,Sotirios Tsimikas,Seppo Ylä-Herttuala +14 more
TL;DR: Myocardial perfusion increased at 1 year in the treated areas with impaired MPR at baseline, and Plasma Lp(a) may be a potential biomarker to identify patients that may have the greatest benefit with this therapy.
Differential expression of cytoplasmic carbonic anhydrases, CA I and II, and membrane-associated isozymes, CA IX and XII, in normal mucosa of large intestine and in colorectal tumors.
Antti Kivelä,Juha Saarnio,Tuomo J. Karttunen,Jyrki Kivelä,Anna-Kaisa Parkkila,Silvia Pastorekova,Jaromir Pastorek,Abdul Waheed,William S. Sly,Seppo Parkkila,Hannu Rajaniemi +10 more
TL;DR: While the normal mucosa of the large intestine showed high expression for CA I and II, the intensity of the immunostaining for both isozymes decreased in benign lesions and was very weak in malignant tumors, suggesting that CA IX and XII may be functionally involved in tumor progression to malignancy and/or in invasion.
83
Angiogenesis, Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor-BB Expression, Iron Deposition, and Oxidation-Specific Epitopes in Stented Human Coronary Arteries
Jan Hinrich Bräsen,Antti Kivelä,Kerstin Röser,Tuomas T. Rissanen,Mari Niemi,Friedrich C. Luft,Karl Donath,Seppo Ylä-Herttuala +7 more
TL;DR: In-stent restenosis features neovascularization, VEGF-A and platelet-derived growth factor-BB expression, and iron deposition, which is most probably derived from microhemorrhages, which may play an important role in the development of neointimal thickening.
80
Expression of a novel carbonic anhydrase, CA XIII, in normal and neoplastic colorectal mucosa
Laura Kummola,Jonna M Hämäläinen,Jyrki Kivelä,Antti Kivelä,Juha Saarnio,Tuomo J. Karttunen,Seppo Parkkila,Seppo Parkkila +7 more
TL;DR: The results indicated that the expression of CA XIII is down-regulated in tumor cells compared to the normal tissue, and may result from reduced levels of a common transcription factor or loss of closely linked CA1, CA2 and CA13 alleles on chromosome 8.