Antony Crisp
Ludwig Maximilian University of Munich
17 Papers
38 Citations
Antony Crisp is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Chemistry & RNA. The author has an hindex of 6, co-authored 12 publications. Previous affiliations of Antony Crisp include Australian National University & Center for Integrated Protein Science Munich.
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Papers
Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides
Sidney Becker,Sidney Becker,Jonas Feldmann,Stefan Wiedemann,Hidenori Okamura,Hidenori Okamura,Christina Schneider,Katharina Iwan,Katharina Iwan,Antony Crisp,Martin Rossa,Tynchtyk Amatov,Tynchtyk Amatov,Thomas Carell +13 more
TL;DR: The synthesis of the pyrimidine nucleosides from small molecules and ribose is reported, driven solely by wet-dry cycles and is compatible with purine synthesis, allowing the concurrent formation of all Watson-Crick bases.
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Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis
Sidney Becker,Christina Schneider,Hidenori Okamura,Antony Crisp,Tynchtyk Amatov,Milan Dejmek,Thomas Carell +6 more
TL;DR: It is reported that geothermal fields could provide the right setup for establishing wet–dry cycles that allow for the synthesis of RNA nucleosides by continuous synthesis by simple changes of physical parameters such as temperature, pH and concentration.
A Click Chemistry Approach to Developing Molecularly Targeted DNA Scissors
Teresa Lauria,Creina Slator,Vickie McKee,Vickie McKee,Markus Müller,Samuele Stazzoni,Antony Crisp,Thomas Carell,Andrew Kellett +8 more
TL;DR: A click chemistry-based di-copper binding ligand was developed to accommodate designer ancillary ligands such as DPQ and DDPZ and, when inserted into a TFO, a dramatic improvement in targeted oxidative cleavage is afforded.
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Non-canonical nucleosides and chemistry of the emergence of life.
TL;DR: Prebiotic chemistry, driven by changing environmental parameters provides canonical and a multitude of non-canonical nucleosides, which suggests that Watson-Crick base pairs were selected from a diverse pool of nucleoside in a pre-Darwinian chemical evolution process.
Amino Acid Modified RNA Bases as Building Blocks of an Early Earth RNA-Peptide World.
Milda Nainytė,Felix Müller,Giacomo Ganazzoli,Chun-Yin Chan,Antony Crisp,Daniel Globisch,Thomas Carell +6 more
TL;DR: It is shown that adenosines lose their base pairing properties, which allow them to equip RNA with amino acids independent of the sequence context, and may be considered to be living molecular fossils of an extinct molecular RNA‐peptide world.
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