Antonio M. Gotto
Cornell University
765 Papers
13.6K Citations
Antonio M. Gotto is an academic researcher from Cornell University. The author has contributed to research in topics: Cholesterol & Lipoprotein. The author has an hindex of 107, co-authored 756 publications. Previous affiliations of Antonio M. Gotto include Baylor College of Medicine & Harvard University.
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Papers
Adipogenic differentiating agents regulate expression of fatty acid binding protein and CD36 in the J744 macrophage cell line
TL;DR: Differences in the regulation of aP2 in adipocytes and macrophages are demonstrated and show that macrophage aP1 expression by adipogenic agents is independent of the PPARγ and/or C/EBPα signaling pathway.
Air force/texas coronary atherosclerosis prevention study (afcaps/texcaps): Additional perspectives on tolerability of long-term treatment with lovastatin
John R. Downs,Michael Clearfield,H.Alfred Tyroler,Edwin J. Whitney,William Kruyer,Alexandra Langendorfer,Vladimir Zagrebelsky,Stephen E. Weis,Deborah R. Shapiro,Polly A. Beere,Antonio M. Gotto +10 more
TL;DR: Treatment with lovastatin 20 to 40 mg daily for primary prevention of coronary heart disease was well tolerated and reduced the risk of first acute coronary events without increasing the riskof either noncardiovascular mortality or cancer.
The phospholipid-binding and immunochemical properties of amidinated, guanidinated and acetylated apolipoprotein A-II.
TL;DR: It is concluded that retaining the positive charges by amidination or guanidination or neutralizing the positive charge by acetylation does not affect the lipid-binding or immunochemical properties of apolipoprotein A-II.
Effective Lowering of Plasma, LDL, and Esterified Cholesterol in LDL Receptor–Knockout Mice by Adenovirus-Mediated Gene Delivery of ApoB mRNA Editing Enzyme (Apobec1)
Ba-Bie Teng,Brian Y. Ishida,Trudy M. Forte,Scott Blumenthal,Li Zhen Song,Antonio M. Gotto,Lawrence Chan +6 more
TL;DR: In the absence of a functioning LDL receptor, hepatic overexpression of Apobec1 is highly efficient in lowering plasma apoB-100 levels, leading to the almost complete elimination of LDL particles and a reduction in LDL cholesterol and cholesteryl ester content.
Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis
Suet Nee Chen,Suet Nee Chen,Mehmet Cilingiroglu,Josh Todd,Raffaella Lombardi,James T. Willerson,Antonio M. Gotto,Christie M. Ballantyne,Christie M. Ballantyne,Ali J. Marian +9 more
TL;DR: Putatively functional variants of APOA2, APOA5, APOC2, CETP, LPL, LIPC and SOAT2 are independent genetic determinants of plasma HDL-C levels and its progression.