Antonio M. Gotto
Cornell University
765 Papers
13.6K Citations
Antonio M. Gotto is an academic researcher from Cornell University. The author has contributed to research in topics: Cholesterol & Lipoprotein. The author has an hindex of 107, co-authored 756 publications. Previous affiliations of Antonio M. Gotto include Baylor College of Medicine & Harvard University.
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Papers
Kinetics and mechanism of transfer of synthetic model apolipoproteins.
Diane L. M. Hickson-Bick,Roger D. Knapp,James T. Sparrow,Doris A. Sparrow,Antonio M. Gotto,John B. Massey,Henry J. Pownall +6 more
TL;DR: The results showed that, unlike lipid transfer, peptide transfer is not always a simple unimolecular process, however, the transfer rates are a predictable function of hydrophobicity.
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Targeting high-risk young patients for statin therapy.
TL;DR: In this issue of JAMA, Wiegman et al report the results of a 2-year efficacy study of pravastatin compared with placebo in 214 children with heterozygous familial hypercholesterolemia and suggest that delaying the start of drug therapy until after adolescence still may translate into future coronary protection.
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Kinetics of tryptic hydrolysis as a probe of the structure of human plasma apolipoprotein A-II
TL;DR: The reduced susceptibility to tryptic hydrolysis of apolipoprotein A-II associated with phospholipid appears to be due to a higher free energy of stabilization of protein secondary structure, which is found to be in regions defined by a high helical amphipathic moment.
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Extending the benefit ef lipid-reguulating therapy to primary prevention
Peter B. Jones,Antonio M. Gotto +1 more
TL;DR: Investigations will extend the results of earlier primary prevention trials and further characterize the rationale for intervention in the role of lipid-regulating therapy in primary prevention.
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Statin Therapy and Reduced Incidence of Stroke: Implications of Cholesterol-Lowering Therapy for Cerebrovascular Disease
TL;DR: Current prevention strategies focus on medical management of hypertension, the most widely recognized stroke risk factor, and lifestyle interventions that are thought to decrease risk, such as smoking cessation, alcohol moderation, increase in physical activity, and weight loss.
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