Antonio Groppetti
University of Milan
45 Papers
999 Citations
Antonio Groppetti is an academic researcher from University of Milan. The author has contributed to research in topics: Dopamine & Dopaminergic. The author has an hindex of 22, co-authored 45 publications.
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Papers
•Journal Article
A simple procedure for calculating the synthesis rate of norepinephrine, dopamine and serotonin in rat brain
TL;DR: With this new procedure, it will be possible to either correlate animal behavior with the rate of amine formation in various brain structures or to study the effect of drugs on brain monoamine synthesis rates.
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Significance of dopamine metabolites in the evaluation of drugs acting on dopaminergic neurons.
Anna Maria Di Giulio,Antonio Groppetti,Flaminio Cattabeni,Corrado L. Galli,Adriana Maggi,Sergio Algeri,F. Ponzio +6 more
TL;DR: Cocaine, nomifensine and d-amphetamine increase 3-MT concentrations while gamma-butyrolactone, alpha-methyltyrosine and apomorphine decrease it, and drugs believed to increase or decrease DA content in the synaptic cleft produce predictable changes of striatal 3- MT.
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Changes in specific activity of dopamine metabolites as evidence of a multiple compartmentation of dopamine in striatal neurons.
Antonio Groppetti,Sergio Algeri,Flaminio Cattabeni,A.M. Di Giulio,Corrado L. Galli,F. Ponzio,PierFranco Spano +6 more
TL;DR: The functional status of dopaminergic nerve terminals has been studied with a method that allows the simultaneous determination of the specific activities of dopamine, tyrosine, 3‐methoxytyramine and 3,4‐dihydroxyphenylacetic acid after administration of [3H]tyrosine.
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Effect of aspirin on serotonin and met-enkephalin in brain: correlation with the antinociceptive activity of the drug.
Antonio Groppetti,Pier Carlo Braga,Gabriele Biella,Marco Parenti,L. Rusconi,Paolo Mantegazza +5 more
TL;DR: Intravenous administration of acetyl salicylate of lysine, a soluble salt of aspirin, reduced in rats the firing discharge of thalamic neurones, evoked by noxious stimuli, indicating that a serotonin- but not a naloxone-sensitive opiate mechanism, may be relevant for aspirin-mediated antinociception.
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Nefopam inhibits calcium influx, cGMP formation, and NMDA receptor-dependent neurotoxicity following activation of voltage sensitive calcium channels
TL;DR: The novel action of nefopam may be important both for its central analgesic effects and for its potential therapeutic use in neurological and neuropsychiatric disorders involving an excessive glutamate release.
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