Antonio Diaz

TL;DR: In this article, the role of chaperone-mediated autophagy (CMA) in neuronal proteostasis was investigated using mouse models with systemic and neuronal-specific CMA blockage, showing that loss of neuronal CMA leads to altered neuronal function, selective changes in the neuronal metastable proteome, and proteotoxicity, all reminiscent of brain aging.

TL;DR: The authors showed that chaperone-mediated autophagy, a selective form of lysosomal protein degradation, is involved in sustaining haematopoietic stem cells function in adult mice.

TL;DR: A complex interplay between the multiple modifications of tau and selective forms of autophagy that may determine its physiological degradation and its faulty clearance in the disease context is unveiled.

TL;DR: It is found that KFERQ-like motifs are more frequently located in solvent-exposed regions of proteins, and that the position of acidic and hydrophobic residues in the motif plays the most important role in motif construction.