Antoine M. van Oijen

TL;DR: It is shown here that the molecular origin of this newly found plasticity lies in the 500-fold increase in strength of the interaction between the polymerase holoenzyme and the replicative helicase upon association of the primase with the replisome.

TL;DR: Current work involves the characterization of the role of the different protein domains in sliding, and the C-terminus of p53 is suggested to be responsible for keeping the protein in contact with DNA by non-specifically interacting with the negatively charged backbone of DNA, while the core domain is suggestedTo locate its target site on DNA, a transcription factor must recognize its site amongst millions to billions of alternative sites on DNA.

TL;DR: An in vitro fluorescence-based assay to monitor internal acidification of individual virions triggered to undergo membrane fusion shows that rimantadine, an inhibitor of M2 proton conductance, blocks the acidification-dependent dissipation of fluorescence from a pH-sensitive virus-content probe.

TL;DR: It is shown that replication complexes pre‐assembled on DNA support synthesis of multiple Okazaki fragments in the absence of excess β clamps, expanding the understanding of lagging‐strand synthesis and emphasizing the stability of the replisome to continue synthesis without new clamps.