Antoine Devisme
University of Freiburg
6 Papers
1 Citations
Antoine Devisme is an academic researcher from University of Freiburg. The author has contributed to research in topics: Biology & Cancer research. The author has an hindex of 1, co-authored 4 publications.
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Papers
Spatially confined sub-tumor microenvironments in pancreatic cancer.
Barbara Grünwald,Antoine Devisme,Geoffroy Andrieux,Foram Vyas,Kazeera Aliar,Curtis W. McCloskey,Andrew Macklin,Gun Ho Jang,Robert E. Denroche,Joan Miguel Romero,Prashant Bavi,Peter Bronsert,Faiyaz Notta,Grainne M. O'Kane,Julie M. Wilson,Jennifer J. Knox,Laura Tamblyn,Molly Udaskin,Nikolina Radulovich,Sandra Fischer,Melanie Boerries,Melanie Boerries,Steven Gallinger,Thomas Kislinger,Thomas Kislinger,Rama Khokha,Rama Khokha +26 more
TL;DR: In this paper, the authors deconvolute the human pancreatic TME through large-scale integration of histology-guided regional multi-OMICs with clinical data and patient-derived preclinical models.
284
Canonical BMP Signaling Executes Epithelial-Mesenchymal Transition Downstream of SNAIL1.
Patrick Frey,Antoine Devisme,Monika Schrempp,Geoffroy Andrieux,Geoffroy Andrieux,Melanie Boerries,Andreas Hecht +6 more
TL;DR: It is demonstrated that SNAIL1 critically relies on bone morphogenetic protein (BMP) signaling for EMT execution, and a signature of BMP-dependent genes in the EMT-transcriptome is defined, which orchestrate E MT-induced invasiveness and are found to be regulated in human CRC transcriptomes and in developmental EMT processes.
22
SMAD4 mutations do not preclude epithelial-mesenchymal transition in colorectal cancer.
Patrick Frey,Antoine Devisme,Katja Rose,Monika Schrempp,Vivien Freihen,Geoffroy Andrieux,Geoffroy Andrieux,Melanie Boerries,Melanie Boerries,Andreas Hecht +9 more
TL;DR: In this article, SMAD4-mutant (SMAD4mut) cancer cells are shown to exhibit morphological changes, become invasive, and regulate EMT marker genes upon induction of the EMT-TF SNAIL1.
21
Spatially confined sub-tumor microenvironments orchestrate pancreatic cancer pathobiology
Barbara Grünwald,Antoine Devisme,Geoffroy Andrieux,Geoffroy Andrieux,Foram Vyas,Foram Vyas,Kazeera Aliar,Curtis W. McCloskey,Andrew Macklin,Gun Ho Jang,Robert E. Denroche,Joan Miguel Romero,Prashant Bavi,Prashant Bavi,Peter Bronsert,Faiyaz Notta,Faiyaz Notta,Faiyaz Notta,Grainne M. O'Kane,Grainne M. O'Kane,Julie M. Wilson,Jennifer J. Knox,Jennifer J. Knox,Laura Tamblyn,Nikolina Radulovich,Sandra Fischer,Melanie Boerries,Melanie Boerries,Steven Gallinger,Thomas Kislinger,Thomas Kislinger,Rama Khokha,Rama Khokha +32 more
TL;DR: In this article, the authors deconvolute regional heterogeneity in the human PDAC tumor microenvironment (TME), a long-standing obstacle, to define precise stromal contributions to PDAC progression.
Abstract A031: Proteogenomic analysis of the PDAC epithelium reveals tissue markers of subtype identity and biology
Barbara Grünwald,Foram Vyas,Michael Geuenich,N. Chan,R. González,Kazeera Aliar,Niklas Krebs,Antoine Devisme,Geoffroy Andrieux,Gun Ho Jang,Grainne M. O'Kane,Julie M. Wilson,Jennifer J. Knox,Faiyaz Notta,Kieran Campbell,Steven Gallinger,Melanie Boerries,Sandra Fischer,Thomas Kislinger,Rama Khokha +19 more
TL;DR: Grünwald et al. as discussed by the authors analyzed the molecular composition of human pancreatic ductal adenocarcinoma (PDAC) epithelia and assessed differentially expressed genes for their ability to discriminate between subtypes and mirror their key biological traits.