Anthony P. Brown
California National Primate Research Center
18 Papers
3 Citations
Anthony P. Brown is an academic researcher from California National Primate Research Center. The author has contributed to research in topics: Biology & Population. The author has an hindex of 7, co-authored 15 publications. Previous affiliations of Anthony P. Brown include Washington State University.
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Papers
Convergent evolution of conserved mitochondrial pathways underlies repeated adaptation to extreme environments
Ryan Greenway,Nicholas Barts,Chathurika Henpita,Anthony P. Brown,Lenin Arias Rodriguez,Carlos M. Rodríguez Peña,Sabine Arndt,Gigi Y. Lau,Michael P. Murphy,Lei Wu,Dingbo Lin,Michael Tobler,Joanna L. Kelley,Jennifer H. Shaw +13 more
TL;DR: It is found that mitochondrial function is maintained in the presence of H2S in sulfide spring P. mexicana but not ancestral lineages from nonsulfidic habitats due to convergence adaptations in the primary toxicity target and a major detoxification enzyme.
microRNA expression variation as a potential molecular mechanism contributing to adaptation to hydrogen sulphide.
Joanna L. Kelley,Thomas Desvignes,Kerry L. McGowan,Marcos A. Perez,Lenin Arias Rodriguez,Anthony P. Brown,Zach Culumber,Michael Tobler +7 more
TL;DR: This study characterized miRNAs and their expression in Poecilia mexicana, a species of small fish that inhabits both normal streams and extreme environments in the form of springs rich in toxic hydrogen sulphide (H2S), and identified a large population of mature miRNA genes that were differentially expressed between locally adapted populations in contrasting habitats, indicating that miRN as may contribute to P. mexicaana adaptation to sulphidic environments.
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Complexities of gene expression patterns in natural populations of an extremophile fish (Poecilia mexicana, Poeciliidae).
Courtney N. Passow,Anthony P. Brown,Lenin Arias-Rodriguez,Muh Ching Yee,Alexandra Sockell,Manfred Schartl,Wesley C. Warren,Carlos Bustamante,Joanna L. Kelley,Michael Tobler +9 more
TL;DR: The majority of variation in gene expression was correlated with organ type, and the presence of specific environmental stressors elicited unique expression differences among organs, potentially indicating that physiochemical stressors with clear biochemical consequences can constrain the diversity of adaptive solutions that mitigate their adverse effects.
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Concordant Changes in Gene Expression and Nucleotides Underlie Independent Adaptation to Hydrogen-Sulfide-Rich Environments.
TL;DR: Comparing populations of fish that have independently adapted to hydrogen-sulfide-rich environments in southern Mexico to adjacent populations residing in nonsulfidic waters concludes that considering both differential expression and changes in DNA sequence led to a more comprehensive understanding of how these populations adapted to extreme environmental conditions.
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The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures
Tao Zhu,Anthony P. Brown,Hong Ji,Hong Ji +3 more
- 03 Mar 2020
TL;DR: Emerging evidence supporting a critical role of ten-eleven translocation 1 (TET1) in mediating epigenetic processes leading to dysregulation of molecular processes and functions is reviewed.