Anthony Nutter
Sanford-Burnham Institute for Medical Research
3 Papers
Anthony Nutter is an academic researcher from Sanford-Burnham Institute for Medical Research. The author has contributed to research in topics: Pars compacta & Substantia nigra. The author has an hindex of 3, co-authored 3 publications. Previous affiliations of Anthony Nutter include Torrey Pines Institute for Molecular Studies.
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Papers
Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
Scott D. Ryan,Nima Dolatabadi,Shing Fai Chan,Xiaofei Zhang,Mohd Waseem Akhtar,James C. Parker,Frank Soldner,Carmen R. Sunico,Saumya Nagar,Maria Talantova,Brian Lee,Kevin Lopez,Anthony Nutter,Bing Shan,Elena Molokanova,Yaoyang Zhang,Xuemei Han,Tomohiro Nakamura,Eliezer Masliah,John R. Yates,Nobuki Nakanishi,Aleksander Andreyev,Shu-ichi Okamoto,Rudolf Jaenisch,Rajesh Ambasudhan,Stuart A. Lipton,Stuart A. Lipton +26 more
TL;DR: In this article, a robust, patient-derived stem cell model of Parkinson's disease was used to identify mitochondrial toxin-induced perturbations in A53T α-synuclein (α-syn) mutant cells and isogenic mutation-corrected controls.
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Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription
Scott D. Ryan,Nima Dolatabadi,Shing Fai Chan,Xiaofei Zhang,Mohd Waseem Akhtar,James C. Parker,Frank Soldner,Carmen R. Sunico,Saumya Nagar,Maria Talantova,Brian Lee,Kevin Lopez,Anthony Nutter,Bing Shan,Elena Molokanova,Yaoyang Zhang,Xuemei Han,Tomohiro Nakamura,Eliezer Masliah,John R. Yates,Nobuki Nakanishi,Aleksander Andreyev,Shu-ichi Okamoto,Rudolf Jaenisch,Rajesh Ambasudhan,Stuart A. Lipton,Stuart A. Lipton +26 more
- 01 Dec 2013
TL;DR: Using a robust, patient-derived stem cell model of PD, the MEF2C-PGC1α pathway is identified as a therapeutic target to combat PD and mechanistic insight into gene-environmental interaction (GxE) in the pathogenesis of PD is provided.
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Potential for cell therapy in Parkinson's disease using genetically programmed human embryonic stem cell-derived neural progenitor cells.
Rajesh Ambasudhan,Nima Dolatabadi,Anthony Nutter,Eliezer Masliah,Scott R. McKercher,Stuart A. Lipton +5 more
TL;DR: This review focuses on current state‐of‐the‐art techniques for harnessing hESC‐based strategies toward development of a stem cell therapeutic for Parkinson's disease and describes a novel genetic‐programming approach that may address many of the key challenges that remain in the field and that may hasten clinical translation.