Anthony Collins
Queen's University Belfast
23 Papers
139 Citations
Anthony Collins is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Inward-rectifier potassium ion channel & Calcium. The author has an hindex of 13, co-authored 22 publications. Previous affiliations of Anthony Collins include Saba University School of Medicine & University of Texas Southwestern Medical Center.
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Papers
Steady-state and dynamic properties of cardiac sodium-calcium exchange. Sodium-dependent inactivation.
TL;DR: Sodium-calcium exchange current was isolated in inside-out patches excised from guinea pig ventricular cells using the giant patch method, indicating that voltage dependence of the exchanger did not change during the inactivation process and sodium-dependent inactivation of outward current is attenuated in rate and extent as extracellular calcium is decreased.
Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification.
Scott D. Pegan,Christine Arrabit,Wei Zhou,Witek Kwiatkowski,Anthony Collins,Paul A. Slesinger,Senyon Choe +6 more
TL;DR: Results suggest the cytoplasmic domains of inwardly rectifying K (Kir) channels undergo structural changes to modulate gating and inward rectification.
Steady-state and dynamic properties of cardiac sodium-calcium exchange. Secondary modulation by cytoplasmic calcium and ATP.
TL;DR: Dynamic responses of cardiac sodium-calcium exchange current to changes of cytoplasmic calcium and MgATP were monitored and analyzed in giant membrane patches excised from guinea pig myocytes.
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Cardiac Na(+)-Ca2+ exchange system in giant membrane patches.
TL;DR: Although internal perfusion of cardiac myocytes'O represented a great improvement over previous electrophysiological myocyte techniques, control of the cytoplasmic environment remained inadequate for many purposes.
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A novel dual-fluorescence strategy for functionally validating microRNA targets in 3′ untranslated regions: regulation of the inward rectifier potassium channel Kir2.1 by miR-212
Dana Goldoni,Janet M. Yarham,Mary K. McGahon,Anna O’Connor,Jasenka Guduric-Fuchs,Kevin S Edgar,Denise McDonald,David Simpson,Anthony Collins +8 more
TL;DR: A functional assay for identifying microRNA targets and applying it to the K+ channel Kir2.1 has several advantages over traditional luciferase-based assays including larger sample size, amenability to time course studies and adaptability to high-throughput screening.