Anthonius A. Eze
University of Nigeria, Nsukka
33 Papers
33 Citations
Anthonius A. Eze is an academic researcher from University of Nigeria, Nsukka. The author has contributed to research in topics: Trypanosoma brucei & Biology. The author has an hindex of 15, co-authored 31 publications. Previous affiliations of Anthonius A. Eze include University of Glasgow & College of Health Sciences, Bahrain.
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Papers
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs
Jane C. Munday,Anthonius A. Eze,Anthonius A. Eze,Nicola Baker,Lucy Glover,Caroline Clucas,David Aguinaga Andrés,Manal J. Natto,Ibrahim A. Teka,Jennifer McDonald,Rebecca S. Lee,Fabrice E. Graf,Fabrice E. Graf,Philipp Ludin,Philipp Ludin,Richard Burchmore,C. Michael R. Turner,Andy Tait,Annette MacLeod,Pascal Mäser,Pascal Mäser,Michael P. Barrett,David Horn,Harry P. de Koning +23 more
TL;DR: TbA QP2 mediates high-affinity uptake of pentamidine and melaminophenyl arsenicals in trypanosomes and TbAQP2 encodes the previously reported HAPT1 activity, which establishes Tb aQP 2 as an important drug transporter.
Tools for Detection of Schistosomiasis in Resource Limited Settings.
TL;DR: The available diagnostic methods are reviewed and the challenges encountered in diagnosis in resource limited settings are discussed and the need for more funding directed towards the development of affordable diagnostic tools that is affordable for endemic countries as the authors work towards the elimination of the disease.
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Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake.
Jane C. Munday,Karla E. Rojas López,Anthonius A. Eze,V. Delespaux,Jan Van Den Abbeele,T.G Rowan,Michael P. Barrett,Liam J. Morrison,Harry P. de Koning +8 more
TL;DR: It is concluded that TcoAT1 is a transporter for purine nucleosides, not for diminazene, and that expression of T coAT1 did not alter drug sensitivity in trypanosomes.
Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis.
Suman K. Vodnala,Thomas Lundbäck,Esther Yeheskieli,Birger Sjöberg,Anna-Lena Gustavsson,Richard Svensson,Gabriela C. Olivera,Anthonius A. Eze,Harry P. de Koning,Lars Hammarström,Martin E. Rottenberg +10 more
TL;DR: A rapid and efficient synthesis of 2-halogenated cordycepins is presented, also useful synthons for the development of additional novel C2-substituted 3'-deoxyadenosine analogues to be evaluated in development of experimental therapeutics.
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Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein.
Jane C. Munday,Daniel N. A. Tagoe,Daniel N. A. Tagoe,Anthonius A. Eze,Anthonius A. Eze,Jessica A. M. Krezdorn,Karla E. Rojas López,Abdulsalam A. M. Alkhaldi,Fiona McDonald,Jennifer Still,Khalid J. Alzahrani,Khalid J. Alzahrani,Luca Settimo,Luca Settimo,Harry P. de Koning +14 more
TL;DR: Earlier hypotheses of drug binding motifs for TbAT1 validate earlier hypotheses of resistance to diamidine and melaminophenyl arsenical classes of drugs that form the backbone of the pharmacopoeia against African trypanosomiasis.