Annika Keller
University of Zurich
45 Papers
42 Citations
Annika Keller is an academic researcher from University of Zurich. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 12, co-authored 33 publications. Previous affiliations of Annika Keller include ETH Zurich.
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Papers
A molecular atlas of cell types and zonation in the brain vasculature
Michael Vanlandewijck,Michael Vanlandewijck,Liqun He,Maarj A. Andaloussi Mäe,Johanna Andrae,Koji Ando,Francesca Del Gaudio,Khayrun Nahar,Thibaud Lebouvier,Thibaud Lebouvier,Bàrbara Laviña,Leonor Gouveia,Ying Sun,Elisabeth Raschperger,Markus Räsänen,Yvette Zarb,Naoki Mochizuki,Annika Keller,Urban Lendahl,Christer Betsholtz,Christer Betsholtz +20 more
TL;DR: The transcriptional basis of the gradual phenotypic change along the arteriovenous axis is uncovered and unexpected cell type differences are revealed: a seamless continuum for endothelial cells versus a punctuated continuum for mural cells.
Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types.
Liqun He,Michael Vanlandewijck,Michael Vanlandewijck,Maarja Andaloussi Mäe,Johanna Andrae,Koji Ando,Francesca Del Gaudio,Khayrun Nahar,Thibaud Lebouvier,Thibaud Lebouvier,Bàrbara Laviña,Leonor Gouveia,Ying Sun,Elisabeth Raschperger,Åsa Segerstolpe,Jianping Liu,Sonja Gustafsson,Markus Räsänen,Yvette Zarb,Naoki Mochizuki,Annika Keller,Urban Lendahl,Christer Betsholtz,Christer Betsholtz +23 more
TL;DR: The dataset constitutes a comprehensive molecular atlas of vascular and vessel-associated cell types in the mouse brain and lung, and as such provides a strong foundation for future studies of vascular development and diseases.
Analysis of the brain mural cell transcriptome.
Liqun He,Michael Vanlandewijck,Michael Vanlandewijck,Elisabeth Raschperger,Elisabeth Raschperger,Maarja Andaloussi Mäe,Bongnam Jung,Thibaud Lebouvier,Koji Ando,Jennifer J. Hofmann,Annika Keller,Christer Betsholtz,Christer Betsholtz +12 more
TL;DR: The reported gene catalogue facilitates identification of brain pericytes by providing numerous new candidate marker genes and is a rich source for new hypotheses for future studies of brain mural cell physiology and pathophysiology.
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Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity
Koen Veys,Zheng Fan,Moheb Ghobrial,Moheb Ghobrial,Ann Bouché,Melissa García-Caballero,Kim Vriens,Nadine V. Conchinha,Aline Seuwen,Felix Schlegel,Tatiane Gorski,Melissa Crabbé,Paola Gilardoni,Raphaela Ardicoglu,Johanna Schaffenrath,Cindy Casteels,Gino De Smet,Ilse Julia Smolders,Koen Van Laere,E. Dale Abel,E. Dale Abel,E. Dale Abel,Sarah-Maria Fendt,Aileen Schroeter,Joanna Kalucka,Joanna Kalucka,Anna Rita Cantelmo,Anna Rita Cantelmo,Thomas Wälchli,Annika Keller,Peter Carmeliet,Katrien De Bock +31 more
TL;DR: GLUT1 is the main glucose transporter in ECs and becomes uncoupled from glycolysis during quiescence in a Notch-dependent manner, crucial for developmental CNS angiogenesis and adult CNS homeostasis but does not affect BBB barrier function.
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Single-Cell Analysis of Blood-Brain Barrier Response to Pericyte Loss
Maarja Andaloussi Mäe,Liqun He,Liqun He,Sofia Nordling,Sofia Nordling,Elisa Vazquez-Liebanas,Khayrun Nahar,Bongnam Jung,Xidan Li,Bryan C. Tan,Juat Chin Foo,Amaury Cazenave-Gassiot,Markus R. Wenk,Yvette Zarb,Bàrbara Laviña,Susan E. Quaggin,Marie Jeansson,Marie Jeansson,Chengua Gu,David L. Silver,Michael Vanlandewijck,Michael Vanlandewijck,Eugene C. Butcher,Annika Keller,Christer Betsholtz,Christer Betsholtz +25 more
TL;DR: In this article, pericytes are described as capillary mural cells playing a role in stabilizing newly formed blood vessels during development and tissue repair, and loss of pericyte has been described in several brain d...
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