Annett Hölsken

TL;DR: RNA sequencing on 18 ACP samples and RNA-Seq data from two ACP mouse models are integrated to reveal that cell clusters are molecularly analogous to the enamel knot, a critical signalling centre controlling normal tooth morphogenesis, which supports a new molecular paradigm for understanding ACP tumorigenesis as an aberrant mimic of natural tooth development.

TL;DR: It is shown that fascin, a target gene of β-catenin TCF signalling in colorectal cancer cells and a key component of filopodia, is also involved in this process, suggesting that activated Wnt-signalling serves as a promoter of the epithelial migration machinery by regulating target molecules such as fascin in adaCP tumour cells.

TL;DR: The data suggest EGFR signaling to play a role in cell migration and brain infiltration of adaCP and Targeting the EGfr signaling pathway by gefitinib may present a promising pharmacologic option in the treatment of this challenging tumor disease.

TL;DR: This study demonstrates that DNA methylation analyses are an additional method to classify CP into subtypes, and implicates a role of epigenetic mechanisms in the genesis of the respective CP variants.