Anne M. Buboltz

TL;DR: Combining genomic and phylogenomic analyses using seven additional diverse, newly sequenced Bordetella isolates reveals that multiple mechanisms, such as point mutations, gain or loss of genes, as well as HGTs, contribute to the substantial phenotypic diversity of these versatile subspecies in various hosts.

TL;DR: A novel mining pipeline, Integrative Next-generation Genome Analysis Pipeline (inGAP), guided by a Bayesian principle to detect single nucleotide polymorphisms, insertion/deletions by comparing high-throughput pyrosequencing reads with a reference genome of related organisms.

TL;DR: In this paper, the authors used a combination of approaches to determine which factors contribute to the increased virulence of a Bordetella bronchiseptica lineage and found that the type III secretion system (TTSS) genes were more highly expressed by strain 1289 than strain RB50.

TL;DR: In this article, the authors found that the virulence of B. bronchiseptica strains, as measured by the mean lethal dose, varied widely and this diversity is likely affected by multiple factors, such as host immune status, polymicrobial infection, and strain diversity.