Anne Bugge
Novo Nordisk
6 Papers
18 Citations
Anne Bugge is an academic researcher from Novo Nordisk. The author has contributed to research in topics: Receptor & Cholecystokinin. The author has an hindex of 4, co-authored 6 publications.
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Papers
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand
Linda Yang,Chih-Chuan Chang,Zhe Sun,Dennis Madsen,Haisun Zhu,Søren Berg Padkjær,Xiaoai Wu,Tao Huang,Karin Hultman,Sarah J Paulsen,Jishu Wang,Anne Bugge,Jane Boesen Frantzen,Per Nørgaard,Jacob Jeppesen,Zhiru Yang,Anna Secher,Haibin Chen,Xun Li,Linu M. John,Bing Shan,Zhenhua He,Xiang Gao,Jing Su,Kristian Tage Hansen,Wei Yang,Sebastian Beck Jørgensen +26 more
TL;DR: It is shown that GDF15 binds specifically to GDNF family receptor α-like (GFRAL) with high affinity, and that GFRAL requires association with the coreceptor RET to elicit intracellular signaling in response to GDF 15 stimulation.
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The Role of the Transsulfuration Pathway in Non-Alcoholic Fatty Liver Disease.
Mikkel Werge,Adrian McCann,Elisabeth D. Galsgaard,Dorte Holst,Anne Bugge,Nicolai J. Wewer Albrechtsen,Lise Lotte Gluud +6 more
TL;DR: The transsulfuration pathway (TSP) is a metabolic pathway regulating homocysteine and cysteine metabolism and is vital in controlling sulfur balance in the organism as mentioned in this paper. Precise control of this pathway is critical for maintenance of optimal cellular function.
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PPAR agonists, - Could tissue targeting pave the way?
Anne Bugge,Dorte Holst +1 more
TL;DR: The results and learnings from the clinical trials on PPAR agonism are summarized and the possibilities for tissue targeting of PPAR ligands by using state of the art technology to fuse them to peptides homing selectively to tissues expressing the cognate surface receptor are discussed.
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Cholecystokinin-1 receptor agonist induced pathological findings in the exocrine pancreas of non-human primates.
Niels C. Berg Nyborg,Rikke Kaae Kirk,Anne Sietske de Boer,David Wederkinck Andersen,Anne Bugge,Birgitte Schjellerup Wulff,Inger Thorup,Trine R. Clausen +7 more
TL;DR: Surprisingly, chronic CCK-1R activation constitutes a risk for pancreatitis and trophic actions on the exocrine pancreas in monkeys and clinical development of NN9056 was halted.
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Cloning and characterization of the porcine gastrin/cholecystokinin type 2 receptor.
TL;DR: It is concluded that the pig has a functional CCK‐2 receptor which is highly comparable to the human orthologue and therefore the pig qualifies as a valid preclinical model for the study of human CCK biology and pharmacology.
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