8 Papers
248 Citations
Anna Zal is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: T cell & Biology. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Anna Zal include Medical Research Council.
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Papers
Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy
Priyamvada Jayaprakash,Midan Ai,Arthur Liu,Arthur Liu,Pratha Budhani,Todd Bartkowiak,Todd Bartkowiak,Jie Sheng,Casey R. Ager,Casey R. Ager,Courtney Nicholas,Ashvin R. Jaiswal,Yanqiu Sun,Krishna Shah,Sadhana Balasubramanyam,Nan Li,Guocan Wang,Jing Ning,Anna Zal,Tomasz Zal,Tomasz Zal,Michael A. Curran,Michael A. Curran +22 more
TL;DR: Hypoxia disruption and T cell checkpoint blockade may sensitize some of the most therapeutically resistant cancers to immunotherapy.
B cells solicit their own help from T cells.
TL;DR: It is shown in this paper that B cell presentation in vitro induces a switch to the Th2 subset indicated by production of IL-4, and targetting C5 to B cells in vivo results in the generation of C5- specific antibodies.
249
OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3
Hongbo Hu,George C. Brittain,Jae Hoon Chang,Nahum Puebla-Osorio,Jin Jin,Anna Zal,Yichuan Xiao,Xuhong Cheng,Mikyoung Chang,Yang Xin Fu,Tomasz Zal,Chengming Zhu,Shao Cong Sun +12 more
TL;DR: Findings establish OTUD7B as a crucial regulator of signal-induced non-canonical NF-κB activation and indicate a mechanism of immune regulation that involves OT UD7B-mediated deubiquitination and stabilization of TRAF3.
194
Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation
Jiayi Yu,Xiaofei Zhou,Mikyoung Chang,Mako Nakaya,Jae Hoon Chang,Yichuan Xiao,J. William Lindsey,Stephanie Dorta-Estremera,Wei Cao,Anna Zal,Tomasz Zal,Shao Cong Sun +11 more
TL;DR: It is shown that T-cell-specific ablation of the kinase TBK1 promotes T- cell activation but causes retention of effector T cells in the draining lymph node in a neuroinflammatory autoimmunity model, experimental autoimmune encephalomyelitis (EAE).
Tmic-09glioblastoma stem cell-derived exosomes promote m2 polarization of human monocytes
Konrad Gabrusiewicz,Yuuri Hashimoto,Jun Wei,Maiti Sourindra,David H. Hawke,Xu Li,Shouhao Zhou,John Yu,Shinji Yamashita,Joy Gumin,Anna Zal,Felix Nwajei,Tomasz Zal,Frederick Lang,Laurence J.N. Cooper,Amy B. Heimberger +15 more
TL;DR: Monocytes demonstrated a preferential uptake of GSC-secreted exosomes which then induced a glioma-supportive M2 phenotype, which can be a contributing factor in the M2 skewing within glioblastoma microenvironment.
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