Anna V. Semenchenko
Max Planck Society
40 Papers
516 Citations
Anna V. Semenchenko is an academic researcher from Max Planck Society. The author has contributed to research in topics: Melatonin & Calorie restriction. The author has an hindex of 20, co-authored 39 publications.
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Papers
Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.
Vladimir N. Anisimov,L. M. Berstein,Peter A. Egormin,Tatiana S. Piskunova,Irina G. Popovich,Mark A. Zabezhinski,Irina G. Kovalenko,Tatiana E. Poroshina,Anna V. Semenchenko,Mauro Provinciali,Francesca Re,Claudio Franceschi +11 more
TL;DR: The metformin-treatment significantly decreased the incidence and size of mammary adenocarcinomas in mice and increased the mean latency of the tumors, suggesting that the life-prolonging effects of calorie restriction are due to decreasing IGF-1 levels.
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Metformin slows down aging and extends life span of female SHR mice.
Vladimir N. Anisimov,L. M. Berstein,Peter A. Egormin,Tatiana S. Piskunova,Irina G. Popovich,Mark A. Zabezhinski,Margarita L. Tyndyk,Maria V. Yurova,Irina G. Kovalenko,Tatiana E. Poroshina,Anna V. Semenchenko +10 more
TL;DR: The chronic treatment of female outbred SHR mice with metformin slightly modified the food consumption but decreased the body weight after the age of 20 months, and dramatically extends life span, even without cancer prevention in this model.
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If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.
Vladimir N. Anisimov,Lev M. Berstein,Irina G. Popovich,Mark A. Zabezhinski,Peter A. Egormin,Tatiana S. Piskunova,Anna V. Semenchenko,Margarita L. Tyndyk,Maria N. Yurova,Irina G. Kovalenko,Tatiana E. Poroshina +10 more
- 21 Feb 2011
TL;DR: It is shown that chronic treatment of female outbred SHR mice with metformin started at the age of 3, 9 or 15 months decreased body temperature and postponed age-related switch-off of estrous function and metformIn improves reproductive function when started at any age.
Short Communication Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice
Vladimir N. Anisimov,Mark A. Zabezhinski,Irina G. Popovich,Tatiana S. Piskunova,Anna V. Semenchenko,Margarita L. Tyndyk,Maria N. Yurova,Marina P. Antoch,Mikhail V. Blagosklonny +8 more
- 01 Jan 2010
TL;DR: In this paper, the mTOR inhibitor rapamycin was shown to prevent age-related weight gain, decreases rate of aging, increases lifespan, and suppresses carcinogenesis in transgenic HER-2/neu cancer-prone mice.
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Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence.
Vladimir N. Anisimov,Lora E. Bakeeva,Egormin Pa,O. F. Filenko,E. F. Isakova,Vasily N. Manskikh,V. M. Mikhelson,Alisa A. Panteleeva,Elena G. Pasyukova,D. I. Pilipenko,T. S. Piskunova,Irina G. Popovich,N. V. Roshchina,O. Yu. Rybina,V. B. Saprunova,T. A. Samoylova,Anna V. Semenchenko,Maxim V. Skulachev,Irina Spivak,E. A. Tsybul’ko,Tyndyk Ml,M. Yu. Vyssokikh,Maria N. Yurova,M. A. Zabezhinsky,Vladimir P. Skulachev +24 more
TL;DR: Data summarized here and in the preceding papers of this series suggest that mitochondria-targeted antioxidant SkQ1 is competent in slowing down execution of an aging program responsible for development of age-related senescence.
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