Anna Spik
Polish Academy of Sciences
14 Papers
42 Citations
Anna Spik is an academic researcher from Polish Academy of Sciences. The author has contributed to research in topics: Germ cell & Gene. The author has an hindex of 9, co-authored 14 publications.
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Papers
Mutations of NANOS1, a human homologue of the Drosophila morphogen, are associated with a lack of germ cells in testes or severe oligo-astheno-teratozoospermia
Kamila Kusz-Zamelczyk,Marcin Sajek,Anna Spik,Renata Glazar,Piotr Jedrzejczak,Anna Latos-Bielenska,Maciej Kotecki,Leszek Pawelczyk,Jadwiga Jaruzelska +8 more
TL;DR: This is the first report describing the association of NANOS1 gene mutations with human infertility, and it is demonstrated that two different infertility phenotypes may reflect distinct functions of N-terminal versus C-Terminal regions of N ANOS1.
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The highly conserved NANOS2 protein: testis-specific expression and significance for the human male reproduction
Kamila Kusz,L. Tomczyk,Marcin Sajek,Anna Spik,Anna Latos-Bielenska,Piotr Jedrzejczak,Leszek Pawelczyk,Jadwiga Jaruzelska +7 more
TL;DR: It is found that NANOS2 protein is present in prenatal germ cells and at later stages in spermatogenesis, and it is testis specific.
SPIN1 is a proto-oncogene and SPIN3 is a tumor suppressor in human seminoma.
Damian M. Janecki,Marcin Sajek,Maciej J Smialek,Maciej Kotecki,Maciej Kotecki,Barbara Ginter-Matuszewska,Bogna Kuczynska,Anna Spik,Tomasz Kolanowski,Tomasz Kolanowski,Riko Kitazawa,Maciej Kurpisz,Jadwiga Jaruzelska +12 more
TL;DR: The findings suggest that acting, at least in part, through SPIN1 and SPIN3, PUM proteins contribute to a mechanism promoting normal human male germ cell apoptotic status and thus preventing cancer.
PUM1 and PUM2 exhibit different modes of regulation for SIAH1 that involve cooperativity with NANOS paralogues
Marcin Sajek,Damian M. Janecki,Maciej J Smialek,Barbara Ginter-Matuszewska,Anna Spik,Sławomir Oczkowski,Erkut Ilaslan,Kamila Kusz-Zamelczyk,Maciej Kotecki,Maciej Kotecki,Jacek Blazewicz,Jacek Blazewicz,Jadwiga Jaruzelska +12 more
TL;DR: Mechanistic differences between PUM1 and PUM2 and between NANOS1, 2, and 3 paralogues in the regulation of SIAH1 are shown and the first report, to the best of the authors' knowledge, showing that an NANos protein directly binds RNA is reported, which highlights the mechanistic versatility of the PUM/NANOS machinery in mammalian posttranscriptional regulation.
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The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells.
Barbara Ginter-Matuszewska,Anna Spik,Alina Rembiszewska,C. Koyias,Jolanta Kupryjanczyk,Jadwiga Jaruzelska +5 more
TL;DR: The presence of a coiled-coil domain responsible for protein-protein interaction could enable SNAPIN to be an adaptor of PUMILIO2 and NANOS1, binding other factors to regulate translation in the development of the human germ cells.
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