Anna Rita Cantelmo
Katholieke Universiteit Leuven
24 Papers
5 Citations
Anna Rita Cantelmo is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Angiogenesis & Endothelial stem cell. The author has an hindex of 15, co-authored 20 publications. Previous affiliations of Anna Rita Cantelmo include university of lille & Flanders Institute for Biotechnology.
Chat about Author
Papers
Role of PFKFB3-Driven Glycolysis in Vessel Sprouting
Katrien De Bock,Maria Georgiadou,Sandra Schoors,Anna Kuchnio,Brian W. Wong,Anna Rita Cantelmo,Annelies Quaegebeur,Bart Ghesquière,Sandra Cauwenberghs,Guy Eelen,Li-Kun Phng,Inge Betz,Bieke Tembuyser,Katleen Brepoels,Jonathan Welti,Ilse Geudens,Inmaculada Segura,Bert Cruys,Franscesco Bifari,Ilaria Decimo,Raquel Blanco,Sabine Wyns,Jeroen Vangindertael,Susana Rocha,Russel T Collins,Sebastian Munck,Dirk Daelemans,Hiromi Imamura,Roland Devlieger,Mark H. Rider,Paul P. Van Veldhoven,Frans Schuit,Ramon Bartrons,Johan Hofkens,Peter Fraisl,Sucheta Telang,Ralph J. DeBerardinis,Luc Schoonjans,Stefan Vinckier,Jason Chesney,Holger Gerhardt,Holger Gerhardt,Mieke Dewerchin,Peter Carmeliet +43 more
TL;DR: It is shown that ECs relied on glycolysis rather than on oxidative phosphorylation for ATP production and that loss of the gly colytic activator PFKFB3 in ECs impaired vessel formation.
1.3K
Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy
Anna Rita Cantelmo,Lena Christin Conradi,Aleksandra Brajic,Jermaine Goveia,Joanna Kalucka,Andreas Pircher,Pallavi Chaturvedi,Johanna Hol,Bernard Thienpont,Laure Anne Teuwen,Sandra Schoors,Bram Boeckx,Joris Vriens,Anna Kuchnio,Koen Veys,Bert Cruys,Lise Finotto,Lucas Treps,Tor Espen Stav-Noraas,Francesco Bifari,Peter C. Stapor,Ilaria Decimo,Kim R. Kampen,Katrien De Bock,Guttorm Haraldsen,Luc Schoonjans,Ton J. Rabelink,Guy Eelen,Bart Ghesquière,Jalees Rehman,Diether Lambrechts,Asrar B. Malik,Mieke Dewerchin,Peter Carmeliet +33 more
TL;DR: It is shown that tumor endothelial cells (ECs) have a hyper-glycolytic metabolism, shunting intermediates to nucleotide synthesis, which reduces cancer cell invasion, intravasation, and metastasis by normalizing tumor vessels by PFKFB3-blockade treatment, which improved vessel maturation and perfusion.
580
Fatty acid carbon is essential for dNTP synthesis in endothelial cells
Sandra Schoors,Ulrike Bruning,Rindert Missiaen,Karla C. S. Queiroz,Gitte Borgers,Ilaria Elia,Annalisa Zecchin,Anna Rita Cantelmo,Stefan Christen,Jermaine Goveia,Ward Heggermont,Lucica Godde,Stefan Vinckier,Paul P. Van Veldhoven,Guy Eelen,Luc Schoonjans,Holger Gerhardt,Mieke Dewerchin,Myriam Baes,Katrien De Bock,Bart Ghesquière,Sophia Y. Lunt,Sarah-Maria Fendt,Peter Carmeliet +23 more
TL;DR: It is reported that endothelial loss of CPT1A, a rate-limiting enzyme of fatty acid oxidation (FAO), causes vascular sprouting defects due to impaired proliferation, not migration, of human and murine endothelial cells.
Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis.
Sandra Schoors,Katrien De Bock,Anna Rita Cantelmo,Maria Georgiadou,Bart Ghesquière,Sandra Cauwenberghs,Anna Kuchnio,Brian W. Wong,Annelies Quaegebeur,Jermaine Goveia,Francesco Bifari,Xingwu Wang,Raquel Blanco,Bieke Tembuyser,Ivo Cornelissen,Ann Bouché,Stefan Vinckier,Santiago Diaz-Moralli,Holger Gerhardt,Holger Gerhardt,Sucheta Telang,Marta Cascante,Jason Chesney,Mieke Dewerchin,Peter Carmeliet +24 more
TL;DR: Although 3PO reduced glycolysis only partially and transiently in vivo, this sufficed to decrease pathological neovascularization in ocular and inflammatory models and may offer therapeutic antiangiogenic opportunities.
503
Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis
Joanna Kalucka,Joanna Kalucka,Laura Bierhansl,Nadine V. Conchinha,Rindert Missiaen,Ilaria Elia,Ulrike Bruning,Samantha Scheinok,Lucas Treps,Anna Rita Cantelmo,Charlotte Dubois,Pauline de Zeeuw,Jermaine Goveia,Annalisa Zecchin,Federico Taverna,Francisco Morales-Rodriguez,Aleksandra Brajic,Lena-Christin Conradi,Sandra Schoors,Ulrike Harjes,Kim Vriens,Gregor-Alexander Pilz,Rongyuan Chen,Richard M Cubbon,Bernard Thienpont,Bert Cruys,Brian W. Wong,Bart Ghesquière,Mieke Dewerchin,Katrien De Bock,Xavier Sagaert,Sebastian Jessberger,Elizabeth A. V. Jones,Bernard Gallez,Diether Lambrechts,Massimiliano Mazzone,Guy Eelen,Xuri Li,Sarah-Maria Fendt,Peter Carmeliet,Peter Carmeliet +40 more
TL;DR: It is reported that QECs are not hypometabolic, but upregulate FAO >3-fold higher than PECs, not to support biomass or energy production but to sustain the tricarboxylic acid cycle for redox homeostasis through NADPH regeneration.
230