Anna Nicolaou
Manchester Academic Health Science Centre
161 Papers
819 Citations
Anna Nicolaou is an academic researcher from Manchester Academic Health Science Centre. The author has contributed to research in topics: Chemistry & Polyunsaturated fatty acid. The author has an hindex of 38, co-authored 145 publications. Previous affiliations of Anna Nicolaou include University College London & University of Bradford.
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Papers
Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2.
Alastair O'Brien,James N. Fullerton,Karen A. Massey,Grace Auld,Gavin W. Sewell,Sarah James,Justine Newson,Effie Karra,Alison Winstanley,William Alazawi,Rita García-Martínez,Joan Cordoba,Anna Nicolaou,Derek W. Gilroy +13 more
TL;DR: Treatment with COX inhibitors or albumin restored immune competence and survival following infection with group B Streptococcus and taken together, human albumin solution infusions may be used to reduce circulating PGE2 levels, attenuating immune suppression and reducing the risk of infection in patients with acutely decompensated cirrhosis or ESLD.
291
The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy
Martin J. Hoogduijn,Felix C. Popp,Richard Verbeek,Mojgan Masoodi,Anna Nicolaou,Carla C. Baan,Marc H. Dahlke +6 more
TL;DR: Some recent literature on the mechanisms of immunomodulation by MSC in vitro and animal models are reviewed, new data on the secretion of pro-inflammatory and anti-inflammatory cytokines, chemokines and prostaglandins are presented and the hopes and expectations of MSC-based immune therapy are discussed.
253
Bioactive lipid mediators in skin inflammation and immunity
TL;DR: This work focuses on psoriasis, atopic and contact dermatitis, acne vulgaris, wound healing and photodermatology that demonstrate dysregulation of bioactive lipid metabolism and examine ways of using this insight to inform novel therapeutics.
227
Lipidomics of oxidized polyunsaturated fatty acids
Karen A. Massey,Anna Nicolaou +1 more
TL;DR: Liquid chromatography coupled to electrospray mass spectrometry offers a versatile and sensitive approach for the analysis of bioactive lipids, allowing specific and accurate quantitation of multiple species present in the same sample.
159
High pancreatic n-3 fatty acids prevent STZ-induced diabetes in fat-1 mice: inflammatory pathway inhibition.
Jérôme Bellenger,Sandrine Bellenger,Amandine Bataille,Karen A. Massey,Anna Nicolaou,Mickaël Rialland,Christian Tessier,Jing X. Kang,Michel Narce +8 more
TL;DR: Findings indicate that fat-1 mice were protected against MLD-STZ–induced diabetes and pointed out for the first time in vivo the beneficial effects of n-3 PUFA at the pancreatic level, on each step of the development of the pathology—inflammation, β-cell damage—through cytokine response and lipid mediator production.