Anna McNally
Beth Israel Deaconess Medical Center
5 Papers
27 Citations
Anna McNally is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: T cell & CD8. The author has an hindex of 4, co-authored 5 publications.
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Papers
Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys
Dan H. Barouch,Dan H. Barouch,Kathryn E. Stephenson,Erica N. Borducchi,Kaitlin M. Smith,Kelly Stanley,Anna McNally,Jinyan Liu,Peter Abbink,Lori F. Maxfield,Michael S. Seaman,Anne-Sophie Dugast,Galit Alter,Melissa Ferguson,Wenjun Li,Patricia L. Earl,Bernard Moss,Elena E. Giorgi,James J. Szinger,Leigh Anne Eller,Erik Billings,Mangala Rao,Sodsai Tovanabutra,Eric Sanders-Buell,Mo Weijtens,Maria G. Pau,Hanneke Schuitemaker,Merlin L. Robb,Jerome H. Kim,Bette T. Korber,Nelson L. Michael +30 more
TL;DR: The capacity of bivalent HIV-1 mosaic antigens to protect rhesus monkeys against acquisition of infection following heterologous challenges with the difficult-to-neutralize simian-human immunodeficiency virus SHIV-SF162P3 is demonstrated.
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Longitudinal Requirement for CD4+ T Cell Help for Adenovirus Vector–Elicited CD8+ T Cell Responses
Nicholas M. Provine,Rafael A. Larocca,Pablo Penaloza-MacMaster,Erica N. Borducchi,Anna McNally,Lily Parenteau,David R. Kaufman,Dan H. Barouch,Dan H. Barouch +8 more
TL;DR: It is demonstrated that induction and maintenance of CD8+ T cell responses by Ad vector immunization is longitudinally dependent on CD4- T cell help for a prolonged period, and insight into the impaired immunogenicity of vaccines in the context of AIDS and other CD4+ Tcell immune deficiencies is provided.
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An attenuated Listeria monocytogenes vector primes more potent simian immunodeficiency virus-specific mucosal immunity than DNA vaccines in mice.
Eung-Jun Im,Erica N. Borducchi,Nicholas M. Provine,Anna McNally,Sufen Li,Fred R. Frankel,Dan H. Barouch,Dan H. Barouch +7 more
TL;DR: It is shown that attenuated recombinant Listeria monocytogenes, administered orally utilizing its natural route of infection, induces potent mucosal as well as systemic immune responses in mice and these responses can be boosted efficiently with replication-incompetent adenoviral vectors.
11
Alternative serotype adenovirus vaccine vectors elicit memory T cells with enhanced anamnestic capacity compared to Ad5 vectors.
Pablo Penaloza-MacMaster,Nicholas M. Provine,Joshua Ra,Erica N. Borducchi,Anna McNally,Nathaniel L. Simmons,Mark Justin Iampietro,Dan H. Barouch,Dan H. Barouch +8 more
TL;DR: The data suggest that vaccination with alternative-serotype Ad vectors offers substantial immunological advantages over Ad5 vectors, in addition to circumventing high baseline Ad5-specific neutralizing antibody titers.