Anna M. Westermark

TL;DR: In this article, the authors show that low glycemic diets can reduce tumour growth by deregulating lipid metabolism, and that KD-driven increases in lipid availability maintain the unsaturated to saturated fatty acid ratios in tumours, and changing the KD fat composition to increase tumour saturated acid levels cooperates with decreased tumour SCD activity.

TL;DR: This work uses computational and experimental approaches to demonstrate that de novo lipid biosynthesis can impose an increased demand for NAD+ in proliferating cancer cells and that environmental lipids are crucial for proliferation in hypoxia or when the mitochondrial electron transport chain is inhibited.

TL;DR: In this article, the authors show that restricting exogenous lipid availability to cultured cancer cells results in up-regulation of stearoyl-CoA desaturase (SCD), an enzyme that converts saturated fatty acids to monounsaturated fatty acids.