The article presents an current knowledge overview about the importance of oxidative stress and reduced efficiency of repair processes during the aging process of the human body. Oxidative damage to cellular macromolecules (proteins, lipids, nucleic acids), are formed under the influence of reactive oxygen species (ROS). They are the part of important mechanism which is responsible for the process of aging and the development of many diseases. The most important effects result from DNA damage, due to the mutations formation, which can lead to the development of tumors. However, a well-functioning repair systems (i.a. homologous recombination) remove the damage and prevent harmful changes in the cells. Lipid peroxidation products also cause oxidative modification of nucleic acids (and proteins). Proteins and fats also have repair systems, but much simpler than those responsible for the repair of nucleic acids. Unfortunately, with increasing age, they are more weakened, which contributes to increase numbers of cell damage, and consequently development of diseases specific to old age: cancer, neurodegenerative diseases or atherosclerosis.

[The correlations between aging of the human body, oxidative stress and reduced efficiency of repair systems].

Summary The article presents an current knowledge overview about the importance of oxidative stress and reduced efficiency of repair processes during the aging process of the human body. Oxi-dative damage to cellular macromolecules (proteins, lipids, nucleic acids), are formed under the influence of reactive oxygen species (ROS). They are the part of important mechanism which is responsible for the process of aging and the development of many diseases. The most important effects result from DNA damage, due to the mutations formation, which can lead to the development of tumors. However, a well - functioning repair systems (i.a. homologous recombination) remove the damage and prevent harmful changes in the cells. Lipid peroxi-dation products also cause oxidative modification of nucleic acids (and proteins). Proteins and fats also have repair systems, but much simpler than those responsible for the repair of nucleic acids. Unfortunately, with increasing age, they are more weakened, which contributes to increase numbers of cell damage, and consequently development of diseases specific to old age: cancer, neurodegenerative diseases or atherosclerosis.aging • oxidative stress • cellular repair mechanisms

Starzenie się organizmu a stres oksydacyjny oraz zmniejszona sprawność systemów naprawczych The correlations between aging of the human body, oxidative stress and reduced efficiency of repair systems

/pdf/wlasciwosci-antyoksydacyjne-miodow-wyznaczone-za-pomoca-hplc-255zlld83x.pdf

Właściwości antyoksydacyjne miodów wyznaczone za pomocą HPLC-ED

O możliwości zastosowania chromatografii cienkowarstwowej do oznaczania całkowitego potencjału antyoksydacyjnego. Część II. Właściwości antyoksydacyjne mięsa

Stress in birds disrupts the homeostasis of the organism, leading to an inability to neutralize reactive oxygen species. Taurine, an effective antioxidant, affects various cellular mechanisms, including cation modulation, protein phosphorylation, and cell proliferation. The aim of the study was to evaluate the effect of colloid with taurine applied in ovo to Albumin on embryonic development, oxidative stress indicators and the content of bioactive peptides—carnosine and anserine—in the pectoral muscle. The research materials were eggs of the parent flock (Ross 308) divided into four groups (K (without injection), T50-concentration of taurine hydrocolloid 50 ppm (mg/L); T100-colloid concentration 100 ppm (mg/L) taurine; T500-colloid concentration of 500 ppm (mg/L) taurine). The experimental solutions were injected in an amount of 0.3 mL into egg white. Eggs were incubated under standard incubation conditions. The addition of 100 and 500 ppm taurine had a highly significant (p = 0.001) effect on the plasma antioxidant potential in chicks. The level of anserine increased with increasing concentrations of taurine. These changes were highly significant (p = 0.007). The level of anserine in the T2 and T3 groups was determined to be 2.5 times higher than in the pectoral muscles of embryos not treated with taurine colloid. An analysis of the results showed that the administration of an increased dose of hydrocolloid with taurine increased the content of carnosine and anserine in the pectoral muscle. Colloid with taurine applied in ovo to chicken white egg reduces oxidative stress and increases homeostasis of the organism. 

Effects of In Ovo Taurine Injection on Embryo Development, Antioxidant Status, and Bioactive Peptide Content in Chicken Embryos (Gallus gallus domesticus)

http://yadda.icm.edu.pl/yadda/element/bwmeta1.element.baztech-62099530-0a99-423e-8dc5-8298cbf948f1/c/nr111s41-66.pdf

Zastosowanie HPLC do oznaczania wolnych rodników, antyoksydantów oraz całkowitego potencjału antyoksydacyjnego

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Zastosowanie HPLC do oznaczania wolnych rodników, antyoksydantów oraz całkowitego potencjału antyoksydacyjnego