Anna Laddach
King's College London
14 Papers
27 Citations
Anna Laddach is an academic researcher from King's College London. The author has contributed to research in topics: Biology & Induced pluripotent stem cell. The author has an hindex of 4, co-authored 11 publications. Previous affiliations of Anna Laddach include Randall Division of Cell and Molecular Biophysics & Francis Crick Institute.
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Papers
TITINdb—a computational tool to assess titin’s role as a disease gene
TL;DR: A web application, TITINdb, is presented, which integrates titin structure, variant, sequence and isoform information, along with pre-computed predictions of the impact of non-synonymous single nucleotide variants, to facilitate the correct classification of titin variants.
43
Genetic variants and protein-protein interactions: a multidimensional network-centric view.
TL;DR: It is discussed how the integration of multiple layers of biological information, in the context of PPINs, can improve the interpretation of genetic variants and inspire new therapeutic strategies.
24
A branching model of cell fate decisions in the enteric nervous system
Anna Laddach,Song Hui Chng,Reena Lasrado,Fränze Progatzky,Michael Shapiro,Artem V. Artemov,Marisol Sampedro Castañeda,Alek Erickson,Ana Carina Bon-Frauches,Jens Kleinjung,Stefan Boeing,Sila K. Ultanir,Igor Adameyko,Vassilis Pachnis +13 more
TL;DR: The studies uncover a novel configuration ofEnteric neurogenesis and gliogenesis that enables the coordinate development of ENS lineages and provides a mechanistic explanation for the ability of enteric glia to be functionally integrated into the adult intestine and simultaneously maintain attributes of early ENS progenitors.
Prediction of Protein-Protein Interactions: Looking Through the Kaleidoscope
Anna Laddach,Sun Sook Chung,Franca Fraternali +2 more
- 01 Jan 2016
TL;DR: Some of the most commonly used computational approaches to the analysis and prediction of protein interaction data are reviewed, with a particular emphasis on the prediction of binary protein complexes and their interfaces.
4
Short loop motif profiling of protein interaction networks in acute myeloid leukaemia
TL;DR: This study proposes a framework for the macroscopic and microscopic investigation of PPINs, their relation to cancers, and highlights important functional modules in the network to be exploited in targeted drug screening.